Hungarian Wound Care Society

Adjuvant Platelet-Rich Fibrin (PRF) Therapy for Wound-Bed Conditioning and Facial Flap Reconstruction: A Systematic Review of Tissue Perfusion and Post-oncological Scar Remodeling - Cureus.com
Article by Alejandro Gonzalez Sr., Hugo David Miranda de la Paz, Paula Andrea Cuenca Cuevas, Stefany Katherine Correa Villavicencio et al. (Colombia, Mexico). PRF is a plausible autologous adjunct for reconstructive wound-bed conditioning. Evidence published from 2022 through 2026 in adjacent clinical contexts suggests potential benefits for skin-graft take, selected soft-tissue healing outcomes, postoperative swelling or pain, and dermal remodeling. Direct clinical evidence for improved perfusion, viability, or scar remodeling in post-oncological facial flaps, however, is lacking.

Adjunctive negative pressure wound therapy in the management of a chronic mixed leg ulcer: A single-case study - PubMed
Abstract by Wee Ting Goh, Nanthakumahrie Gunasegaran and Fazila Aloweni (Singapore - J Vasc Nurs.).

Protective Effect of Prophylactic Negative-Pressure Wound Therapy on Surgical-Site Infection in High-Risk Open Abdominal Surgery: A Retrospective Cohort Study and Nomogram Development - PubMed
Abstract by Fen Zhou, Yuhao Zhang, Ping Yu, Xia Feng et al. (Zheijang, China - Int Wound J.).

Fibrinogen discovery reshapes our understanding of how wounds heal - Manchester.ac.uk
Article by Michael Addelman. Scientists have redefined how the key blood‑clotting protein fibrinogen behaves when it contacts air, overturning two decades of scientific consensus on wound healing. The discovery could have far reaching implications on the treatment of clotting disorders like haemophilia or the healthcare for patients on blood thinners like warfarin, as scabs forming on the surface of blood are vital to sealing a wound and keeping the site free of infection. It could also explain aspects of how a lung can collapse in acute respiratory distress syndrome (ARDS), as fibrinogen disrupts the oily layer that keeps the airways open during breathing.

Cannabis and Wound Healing: A Narrative Review of Current Evidence and Applications to Facial Plastic Surgery - Mdpi.com
Article by Bita Rashed Naimi and David B. Hom (San Diego, USA - JPM). This review summarizes the biologic rationale, available surgical evidence, and clinical considerations for incorporating cannabis use into individualized perioperative risk assessment in facial plastic surgery.

Quinone-mediated, tissue-adaptive double-network hydrogel for instant hemostasis and wet-tissue adhesion - Nih.gov
Article by Tae Young Kim, Kayoung Son, Chang-Hwan Moon, Keun-Young Yook et al. (Republic of Korea, China - Nat. Commun.). The authors show that the hydrogel achieves hemostasis within seconds in a mouse liver hemorrhage model and effectively controls bleeding in large-area liver and spleen injuries in rabbits. They test in a skin incision model to demonstrate that the hydrogel can function as a suture-free adhesive and support healing with minimal scarring.

Skin Grafting for Cobra Bite–Induced Hand Defects: Refining Indications in a Dynamic Wound Environment - Wiley.com
Article by Trần Thiết Sơn, Phan Tuấn Nghĩa and Đặng Phương Nam (Hanoi, Vietnam - International Wound Journal). Skin grafting is a reliable and less invasive option for cobra bite–induced hand defects when performed on a well-prepared wound bed. A staged, mechanism-based reconstructive strategy is proposed. NPWT may contribute to wound-bed optimization, whereas finger defects appear to represent a higher-risk subgroup.

Fibrinogen discovery reshapes understanding of how wounds heal - Phys.org
Article by Sadie Harley. Scientists have redefined how the key blood-clotting protein fibrinogen behaves when it contacts air, overturning two decades of scientific consensus on wound healing. The discovery could have far-reaching implications for treating clotting disorders like hemophilia or providing health care for patients taking blood thinners like warfarin, as scabs that form on the surface of blood are vital to sealing wounds and keeping sites free of infection.

Effects of Moist Wound Healing Strategy on Healing Time of Burn Wound Donor Sites and Patients’ Depression/Anxiety Symptoms - Phys.org
Article by Xifei Miao, Bao Wang, Fang Chen, Ziwei Liang et al. (Nanjing, China - Clinical, Cosmetic and Investigational Dermatology). Moist wound healing with Sanyrene dressing is associated with faster donor site healing, reduced pain, improved skin and scar outcomes, and better psychological well-being compared to traditional dry care in burn patients.

Nanoparticle combines two strategies to speed up the healing of chronic wounds - Phys.org
Article by Sadie Harley. Researchers at the University of São Paulo (USP) in Ribeirão Preto, Brazil, have developed a nanoparticle that can address the various factors hindering the healing of chronic wounds, which include ulcers associated with diabetes and pressure ulcers common among bedridden individuals. These wounds, which may persist for months or even years, affect about 1% to 2% of the population and represent a significant public health concern because they increase the risk of infection and amputation and significantly impair patients' quality of life.

Advancing Chronic Wound Healing: Innovations in Hooked Array Nylon Fabric for Wound Hygiene, Debridement, and Tissue Sampling - Ovid.com
Article by Traci Kimball, Laura Swoboda, Frank Aviles and Neal Lonky (USA - Advances in Skin & Wound Care). This review has highlighted the key advantages of hooked nylon fabric across diverse clinical applications, from outpatient wound clinics to resource-limited home care settings. The integration of hooked nylon fabric into wound hygiene protocols is intended to enhance patient outcomes, reduce health care costs, and support the adoption of advanced therapies such as cellular tissue products. Its role in modulating the immune response and enabling tissue sampling underscores its potential for expanding diagnostic and therapeutic capabilities in chronic wound care. Simple clearance of bioburden, exposing the wound base, can enhance access to other biologic healing drugs or devices intended to heal wounds in a concerted effort.

Effect of Prophylactic Incisional Negative Pressure Wound Therapy on Surgical Site Infection After Emergency Laparotomy: An Updated Meta-Analysis With Trial Sequential Analysis - Wiley.com
Article by Ana Luíza Rocha Soares Menegat, Brenda Luana Rocha Soares Menegat, Sara Bravin, Jacopo Lin and Henrique Wiederkehr (Brazil, Italy - World Journal of Surgery). In patients undergoing emergency laparotomy, iNPWT was associated with reduced odds of SSI and wound-related complications compared with standard dressings. Although iNPWT was associated with higher follow-up mortality, this finding was not confirmed in RCT-only analyses.

Applications of Nanomaterials in Chronic Wound Healing and Scar Prevention - Dovepress.com
Article by Nanxin Zhang, Bendian Song and Rongtao Cui (Shandong, China - Int. J. of Nanomedicine). This review provides a theoretical basis and research guidance for utilizing nanotechnology to overcome barriers to chronic wound healing and prevent pathological scarring.

Extracorporeal shockwave therapy as a key component of interdisciplinary wound management in diabetic foot syndrome - Springer.com
Article by Richard Crevenna, Zoltan Vass, Michael Mickel, Michael Leutner et al. (Vienna, Austria - Wiener Medizinische Wochenschrift). The present case supports the hypothesis that focused ESWT may represent a clinically relevant adjunctive treatment option in selected patients with diabetic foot syndrome and complicated wound healing disorders. At the same time, it highlights the need for prospective randomized controlled trials.

Smart Polymeric Wound Dressings for Wound Treatment: Contributions and Applications - Mdpi.com
Article by Eduard-Gabriel Constantin, Mădălina Georgiana Albu Kaya, Cristina-Elena Dinu-Pîrvu, Lăcrămioara Popa et al. (Bucharest, Romania - IJMS). In this review, the authors summarize recent advances in the design, stimuli-responsive mechanisms, characterization methods, and therapeutic outcomes of smart polymeric dressings for wound treatment. Despite promising preclinical results, challenges related to clinical translation, regulatory standardization, and scalable production remain and must be addressed to facilitate widespread clinical adoption.

Formulation Attributes and Preclinical Wound Healing Outcomes of Natural Product Based Nanoemulsions: A Systematic Review - Dovepress.com
Article by Fauzan Afandi, Ferdy Firmansyah, Angga Cipta Narsa, Gofarana Wila et al. (Indonesia, Egypt, Saudi Arabia - Int. J. of Nanomedicine). The evidence suggests preclinical wound healing activity and formulation relevance; however, methodological heterogeneity and uncertainty in internal validity preclude conclusions regarding clinical efficacy, clinical superiority, or translational readiness.

Recent Advances in Smart Wound Healing Patches: From Passive Dressings to Intelligent Theranostic Systems - Cureus.com
Article by Rahul A. Sachdeo, Akshay R. Yadav, Chitra Khanwelkar and Amol Shete (Karad, India). This study gives a thorough account of recent breakthroughs in wound healing patches, emphasizing material innovations, technological advancements, clinical uses, and future prospects in this rapidly growing subject.

Multifunctional Hydrogel with Phytochemicals and Silver Nanoparticles for Promoting Scar-Free Wound Healing - Mdpi.com
Article by Devadass Jessy Mercy, Koyeli Girigoswami, Pazhani Durgadevi, Venkatakrishnan Kiran and Agnishwar Girigoswami (Chennai, India - Gels). Among the hydrogels, AG-AgNP-PE exhibited superior performance across all key properties, highlighting the synergistic effect of the nanomaterial combined with plant extracts within hydrogel cages and positioning it as a promising multifunctional wound dressing for rapid tissue regeneration and scar-free wound healing, suitable for advanced wound management.

Biomimetic Dermal Substitutes for Skin Reconstruction: Advances in Scaffold Design, Biological Integration, and Clinical Performance - Mdpi.com
Article by Bogdan Mircea Măciuceanu Zărnescu, Iulia Ioana Lungu, Adelina-Gabriela Niculescu, Alexandru Scafa Udriște et al. (Bucharest, Romania - JFB). This structured review introduces the challenges posed by complex skin defects, the limitations of autologous skin grafts and conventional reconstruction techniques, and the emerging field of dermal substitutes and biomimetic scaffolds. Moreover, the native dermis is presented as a blueprint for biomimetic scaffold design, along with key principles to consider when engineering a dermal scaffold, from architecture and porosity to angiogenic potential. A critical examination of the main classes of available dermal substitutes and their clinical performance is conducted, highlighting their limitations and the translational gaps in current evidence.

Advances in Smart Responsive Nanofibers for Wound Healing - Mdpi.com
Article by Ding Xu, Hanpeng Liu, Zijun Hu, Shutao Wei et al. (China - Biomimetics). The incorporation of different types of stimuli constructs smart responsive nanofiber dressings, which not only provides a novel therapeutic strategy for wound healing, but also outlines future research directions for the development of smart responsive nanofibers.

The Future of AI & Remote Monitoring in Wound Care - Axiscare.com
AI tools are reshaping every corner of the home care industry. They’re making it easy to track clients’ vitals remotely, identify trends that improve health outcomes, and even monitor wound progression over time. These digital tools are equally helpful for post-acute wounds as they are for chronic ones, which don’t heal on the typical weeks-to-months timeline. Diabetic foot ulcers or bedsores, for example, require a much more complex scope of intervention compared to a post-surgery site. Given that one in every six Medicare beneficiaries suffers from a chronic wound, this is just one of many high-need areas for active monitoring and intervention.

Microneedle-based platforms for wound healing: recent advances - Nih.gov
Article by Imran Ibni Gani Rather, Bidya Mondal, Syed Muntazir Andrabi and Jingwei Xie (USA - J Mater Chem B.). This review summarizes recent advances in microneedle fabrication methods, structural designs, and integration with other scaffolds. It also discusses diagnostic and sensing capabilities, as well as therapeutic mechanisms across diverse wound types, highlighting the translational potential of multifunctional MN systems for next-generation wound care.

Hemostatic and Wound Healing Nonisocyanate Polyhydroxyurethanes (NIPHUs) Dressings from Soybean Oil: In Vivo Characterization - Pubs.acs.org
Article by Maria Paula Morales-Gonzalez, Manuel F. Valero, Luis Eduardo Díaz, Nallely Álvarez-Santos et al. (Colombia, Mexico - ACS Omega). As a preliminary study, nonisocyanate polyhydroxyurethane 50/50 exhibited hemostatic activity and allowed the wounds to be in the remodeling phase in 14 days, making it suitable for use as a dressing.

Cold Atmospheric Plasma in Wound Healing: Molecular Mechanism of Action - Mdpi.com
Article by Dawid Bińkowski, Bogusław Antoszewski and Anna Kasielska-Trojan (Lodz, Poland - IJMS). The results of studies to date suggest that cold atmospheric plasma may provide valuable support for therapies, particularly in the context of skin regeneration, wound healing and the treatment of inflammatory lesions.

Biological mechanisms and applications of photobiomodulation in wound care - PubMed
Abstract by Emma Hallam (Nottingham, UK - Br J Nurs.).

Healing the Sole: Combining Natural Plant Extracts and Conventional Drugs in Wound Delivery Systems for Diabetic Foot Ulcer Treatment - Mdpi.com
Article by Raneille Quirsten Baligod, Izliah Grace Nicole Fabian, Kristine Margreth Repol, Heidi Lindt Sy et al. (Philippines, Rep. of Korea - IJMS). This review discusses natural product extracts, conventional drugs, combinations, and integration into DDSs, based on wound characteristics. These include depth, infection status, exudate level, and perfusion, as recommended by the 2023 IWGDF guidelines. Three combinations have shown promise in preclinical studies: propolis-charcoal bandages, propolis-oregano microneedles, and Centella-ZnO nanocomposites.

Comparative Wound Healing Processes in Plants and Animals: Bioinspired Strategies for Advancing Regenerative Medicine - Nih.gov
Article by Fatemeh Najafi, Natália Aparecida de Paula, Filipe Rocha Lima, Marcio Fronza et al. (Brazil - Int J Mol Sci.). This review provides a comparative perspective on wound-healing processes in plants and animals and addresses two important challenges in the field: the lack of a broadly organized framework for plant wound healing and the absence of a systematic approach for cross-kingdom comparison, respecting the important differences in the complexity, embryogenesis, biology, and physiology of the processes. By organizing wound-healing responses into three functional phases, bioelectrical signaling, immune responses, and tissue formation and remodeling, we established a common framework that facilitates the systematic analysis of regenerative processes across evolutionarily distant organisms.

Keeping people with dementia moving in hospital to reduce pressure ulcer risk: complexities in care - PubMed
Abstract by Megan Healy (Sheffield, UK - Br J Nurs.).

Junior nurses' wound care knowledge and attitude towards wound care and training aspirations: a training needs analysis - PubMed
Abstract by Fania Pagnamenta, Cheryl Teasdale, Monique Lhussier and Tim Rapley (Newcastle upon Tyne, UK - Br J Nurs.).

Compression for venous leg ulcers: which method works best? - Healthcare-in-europe.com
Compression wraps are unlikely to help venous leg ulcers heal faster than standard compression treatments, according to a clinical trial led by University of Manchester and York researchers. The findings of the study, published in PLOS Medicine and funded by the National Institute of Health and Care Research (NIHR), suggest the wraps may not be the best first-line option for patients receiving strong compression therapy.

Functional Nutrition in Wound Care: Why Nutrition–Medication Interactions Deserve Greater Attention - Woundsource.com
Article by Jennifer J. Spector. Nutrition is increasingly recognized as a foundational component of wound healing, yet nutritional status, medication-related nutrient depletion, and drug–nutrient interactions remain underrecognized contributors to delayed healing and poorer patient outcomes. As patient populations become older, more medically complex, and more likely to receive multiple medications, understanding the intersection of functional nutrition and pharmacotherapy has become an essential competency for wound care professionals.

Bioactive Metabolites of Solanum tuberosum L. in Inflammation Modulation and Tissue Regeneration: A Scoping Review of Wound Healing Mechanisms - Mdpi.com
Article by Wahyu Hidayat, Mieke Hemiawati Satari, Ronny Lesmana, Solachuddin Ichwan and Irna Sufiawati (Indonesia - Biomedicines). Potato-derived bioactive metabolites show multi-target preclinical associations with wound healing and warrant further development as potential adjunctive therapies for mucosal and cutaneous wounds after standardization and clinical validation.

Global burden to local action: A pilot feasibility study of placental-based solutions for complex pressure ulcers using real-world evidenc - Internationaljournaloftissuerepair.com.com
Article by Windy Cole, Caroline Fife, Hongyu Miao and Marshall Medley (USA - IJTR). Although ATM was not associated with a statistically significant improvement in PAR, ATM-treated wounds were more frequently classified as healing or healed based on clinician-assessed outcomes.

Cold Atmospheric Plasma Disrupts Microbial Wound Bioburden: In Vitro, Porcine MRSA Biofilm, and Clinical Fluorescence Evidence from Bench to Bedside - Mdpi.com
Article by Steven Jeffery, Ahmad Wakaf, Lennart Marlinghaus, Sören Gatermann et al. (UK, Germany, USA - Biomedicines). From bench to bedside, the investigated CAP system delivered rapid broad-spectrum antimicrobial activity, reduced MRSA burden in biofilm-infected porcine wounds, and was associated with clinically measurable suppression of wound surface bioburden while remaining tissue-sparing.

Topical strategies for antimicrobial delivery of peptide medicines for the management of chronic wounds - Springer.com
Article by Sasikumar Murthy, Tan Yong Zhao, Vasantha Kumari Neela, Masriana Hassan, Malarvili Selvaraja and Vijayaraj Kumar Palanirajan (Malaysia - Discover Nano). Chronic wounds are challenging to treat due to persistent infections and antibiotic resistance, necessitating innovative therapeutic strategies. This review highlights advanced topical delivery systems for antimicrobial peptides (AMPs) that enhance their stability and efficacy, demonstrating potential for improved healing outcomes in chronic wounds while addressing the limitations of conventional antibiotics.

Biofilm-Responsive Nanoplatforms for Infected Wound Reconstruction - Dovepress.com
Article by Shiyu Cao, Bingran Qi, Pengfei Di, Jiashu Xie et al. (Shenyang, China - International Journal of Nanomedicine). Authors conclude that biofilm-responsive wound nanomedicine must move beyond bacterial killing alone toward validated wound-ecosystem regulation, with stronger emphasis on mature biofilm models, polymicrobial infection, human-relevant tissue testing, long-term scar quality, and reproducible manufacturing. This disciplined design approach is essential for translating biofilm-responsive nanoplatforms from laboratory constructs into clinically credible tools for tissue reconstruction.

Biopolymer-Based Hydrogels for Wound Healing: Advances in Cellulose, Chitosan, Alginate, and Hyaluronic Acid from Design to Clinical Translation - Mdpi.com
Article by Shery Jacob, Namitha Raichel Varkey, Sai H. S. Boddu, Jigar N. Shah et al. (United Arab Emirates, India, Saudi Arabia - Pharmaceuticals). Biopolymer-based hydrogels are a flexible, rapidly developing platform with significant promise to improve next-generation skin tissue engineering and change the treatment of both acute and chronic wounds.

Indigenous Negative-Pressure Wound Therapy vs Conventional Dressing for Abdominal Wound Dehiscence in a Resource-Limited Setting - Cureus.com
Article by Priyanka Kerketta, Arunav Roy, Prabha R. Lakra, Ritvik Prakash and Jyoti Kumari (Ranchi, India). Indigenous NPWT was associated with faster granulation and improvement in early wound-healing parameters, fewer dressing changes, greater early wound-area reduction, and less pain than conventional saline-gauze dressing in postoperative abdominal wound dehiscence. As a low-cost, locally assembled alternative, it offers a practical option for resource-limited settings.

Assessment for prevention and holistic treatment of pressure ulcers in community settings - PubMed
Abstract by Linda Nazarko (UK - Br J Community Nurs.).