Hungarian Wound Care Society

What regenerative medicine can learn from multifunctional biomaterials - Drugtargetreview.com
A multifunctional injectable hydrogel built on a cerium–rutin metal–phenolic nanocomplex could offer a new approach to deep wound repair, combining antioxidant enzyme mimicry, antibacterial activity and moisture regulation within a single platform.

Perspective: Optimizing Host Environments to Enhance MSK Tissue Repair and Complement Use of Cellular Therapies Is Critical for Improving Outcome Success – An Unmet Need - Mdpi.com
Article by David A. Hart (Calgary, Canada - Cells). Considerable research effort over the past >35 years with MSC, iPSC and EV to improve the repair of MSK tissues has met with limited and often variable in vivo success. In contrast, optimizing the host environment via controlling inflammation, modifying tissues altered by chronic injury or disease, as well as host variables (i.e., age, sex, location, genetics, co-morbidities) has not received coordinated attention.

Study on the repair effect of photothermal hydrogel with controllable adhesiveness regulated by melanin and magnesium ions on diabetic wounds - Sciencedirect.com
Article by Lan Guo, Keying Wu, Ruxin Wang, Yadong Xue et al. (China - Bioactive Materials). The photothermal hydrogel possessed ideal adhesion adaptability to different types of wounds and could effectively promote wound repair through hyperthermia. This study provides novel insights and technical support for the clinical treatment of chronic non-healing wounds.

Mineral–Botanical Hybrid Nanofibrous Dressing for Post-Surgical Melanoma Wound Healing - Mdpi.com
Article by Tubanur Avci, Eray Altan, Ceren Aytar, Zehra Kanli et al. (Turkey - Polymers). This study presents a sustainable, dual-function wound dressing that suppresses residual cancer cells while promoting healthy tissue regeneration, offering a promising alternative to conventional synthetic oncological dressings.

Wound Debridement with Copper Oxide Dressings: Bridging the Gap Between Clinical Observations and the Basic Science Underlying Endogenous Autolysis - Mdpi.com
Article by Eyal Melamed and Ithamar Cheyne (Israel, Poland - JFB). The observations support the hypothesis that copper ions and CODs may amplify autolytic tissue clearance through CDPs, with concurrent synergistic interaction between angiogenesis and debridement.

Novel hydrogel offers a smarter approach to wound healing - Eurekalert.org
Any minor cut or scrape sets the body’s natural healing process in motion. However, deep wounds are far more vulnerable to bacterial infection and the accumulation of harmful molecules called reactive oxygen species (ROS) that damage cells and disrupt normal repair mechanisms. These factors can significantly delay healing and increase the risk of complications. With this in mind, researchers from Indian Institute of Technology Gandhinagar (IITGN) have developed an antibiotic-free multifunctional injectable hydrogel designed to accelerate wound healing.

Smart wound dressing speeds up healing by triggering body’s own repair signals - Imperial.ac.uk
Article by Joanna Wilson. A bioinspired material, developed by scientists at Imperial College London, accelerates wound healing and the repair of human skin. The material captures the body’s own healing proteins, releasing them only when repair cells pull on them, delivering healing signals precisely where and when they are needed. In new research published in Nature Materials, the dressings helped wounds on a mouse model close faster and improved the repair of human skin tissue in laboratory tests - the first time this mechanism has been shown to work in living, repairing tissue.

Force-responsive biomaterials drive tissue repair by harnessing endogenous growth factors - Nature.com
Article by Magdalene Y. Ho, Nuria Oliva, Christopher Basu, Marcos R. Rodriguez et al. (London, UK - Nature Materials). The ability to harvest and redeliver endogenous growth factors without exogenous triggers, recombinant proteins or cold-chain logistics via mechanoresponsive biomaterials opens possibilities for accessible, cost-effective combinatorial biologic therapies.

How to Administer Local Anesthesia for Wound Care Procedures - Woundreference.com
Article by Elaine Horibe and Scott A. Robinson. Local anesthesia refers to a temporary, reversible loss of sensation in a defined area of the body, often induced by the application of local anesthetics. Use of local anesthetics should be considered prior to procedures that may cause pain. This topic addresses the clinical use, safety and selection of local anesthetics and local anesthesia techniques used to provide anesthesia prior to procedures commonly performed in wound care (e.g. wound debridement, wound biopsy).

From wound to amputation: A physician explains why diabetic foot ulcers demand urgent attention - Medicaleconomics.com
Article by Richard Payerchin. Epidemiologic burden is substantial: up to one-third of patients with diabetes develop a lifetime foot ulcer, with frequent infection and consequential amputation risk. Patient-reported outcomes deteriorate markedly, with pain, odor, intensive visit cadence, and functional constraints compounding the disability associated with ulceration and limb loss.

Developing Three-Dimensional (3D) Skin Models to Study the Interaction Between the Skin Microbiome and Immune Cells in Chronic Wounds - Cureus.com
Article by Laith Basch, Asha Gopu, Hannah Welp, Mahnoor Mukarram et al. (USA). The incorporation of patient-derived immune cells into 3D co-culture systems further enables personalized modeling of wound-healing deficiencies and antimicrobial-resistance patterns. Applications of 3D skin models extend to the development of antibiofilm agents, immune-modulating therapies, and microbiome-targeted interventions.

Retrospective review of 3126 patients with chronic lower extremity wounds treated with intermittent topical oxygen therapy - Jvsvi.org
Article by Joann M. Lohr, Andrew J.M. Boulton, Anil Hingorani, Palma M. Shaw et al. (USA, UK - Journal of Vascular Surgery). Multi-modality intermittent topical oxygen therapy (ITOT) is an effective, noninvasive, patient-applied therapy that synergistically addresses the root causes of chronicity seen in nonhealing wounds: inflammation, edema, and tissue hypoxia. In this large cohort study, ITOT demonstrated superior wound healing outcomes in complex, comorbid populations, compared with those reported in population-based real-world studies. The results of this study support the durable healing outcomes demonstrated in previously published ITOT randomized controlled trial and real-world evidence studies.

Plantago mechanisms for enhanced wound healing: A review on bioactive phytoconstituents - PubMed
Abstract by Triana Hertiani, Muhammad Khafi, Latifa Amalia and Muhamad Bayu Irawan (Yogyakarta, Indonesia - Chin Herb Med.).

Intensive Care Nurses' Adherence to Evidence-Based Clinical Practice Guidelines for the Prevention and Treatment of Pressure Ulcers and Their Self-Efficacy: A Cross-Sectional - PubMed
Abstract by Özlem Fidan, Arife Şanlialp Zeyrek and Durdu Ok (Denizli, Turkey - Int Wound J.).

Hyaluronic Acid-Based Biomaterials for Soft Tissue Repair and Wound Healing: Clinical Evidence and Emerging Applications - Mdpi.com
Article by Bogdan Mircea Măciuceanu Zărnescu, Diana Cristina Pîrvulescu (Bunea), Adelina-Gabriela Niculescu, Alexandru Scafa Udriște et al. (Bucharest, Romania - Gels). This narrative review covers the clinical evidence for the effectiveness of commercial products for acute and diabetic wounds, as well as burns and chronic wounds, and discusses where their use is indicated. In the end, the current limitations of the research and future applications and directions are discussed.

Toward cell-instructive protein hydrogels for chronic wound repair - Cell.com
Article by Hongbin Li1 Send, Zeyu Zhao1 and Feng Cheng (China - Cell Biomaterials). Using elastin-like recombinamer hydrogels functionalized with laminin-derived peptides via click chemistry and recombinant engineering, the authors created an extracellular matrix (ECM)-mimetic matrix that enhances skin-cell adhesion, migration, and re-epithelialization.

Clay-Based Nanomaterials in Wound Healing: Therapeutic Roles, Mechanisms and Biomedical Applications - Mdpi.com
Article by Alibala Aliyev, Ulviyya Hasanova, Silvia Buroni, Altunay Aliyeva and Aygun Israyilova (Azerbaijan, Italy - Micro). Preclinical and initial clinical investigations have substantiated the biocompatibility, antimicrobial properties, and regenerative capabilities of these systems, although they have also revealed several challenges concerning toxicity, regulatory categorization, and standardization. Clay-based systems present a potentially valuable multifunctional platform for advancing next-generation wound-treatment therapies, necessitating additional translational and clinical research.

Can 3D-printed skin scaffolds improve wound care in Africa? - Nature.com
Article by Engela Duvenage. University of Pretoria pharmacologist Hafiza Parkar is developing personalised collagen structures for chronic wounds, but turning the laboratory technique into an affordable clinical treatment will require further testing.

Wound Debridement with Copper Oxide Dressings: Bridging the Gap Between Clinical Observations and the Basic Science Underlying Endogenous Autolysis - Mdpi.com
Article by Eyal Melamed and Ithamar Cheyne (Israel, China - JFB). The observations support the hypothesis that copper ions and copper oxide-containing dressings may amplify autolytic tissue clearance through copper-dependent pathways, with concurrent synergistic interaction between angiogenesis and debridement.

Global forecasts of decubitus ulcer burden among older adults across sociodemographic settings to 2030 - Nih.gov
Article by Qiang Ren, Kun Dou and Jun Zhao (China - Medicine). Mortality-to-incidence ratio (MIR) relates mortality to diagnosed burden and may help contextualize whether changes in recorded incidence are accompanied by changes in mortality relative to incidence. Decubitus ulcer mortality and MIR may characterize disparities in care continuity, but neither is an official SDG 3.4 indicator.

Effect of Negative Pressure Wound Therapy on Clinical Outcomes For Patients Undergoing Vascular Surgeries - Ekb.eg
Article by Amira Mohamed Elneny, Adel Husseiny kamhawy, Monira Bassuni Elsheimy and Reda Abdelsalam Elbastawesy (Tanta, Egypt - Tanta Scientific Nursing Journal). Negative Pressure Wound Therapy is an effective and safe method for improving wound healing outcomes in patients undergoing vascular surgeries. It accelerates the healing process, reduces complications, and enhances patient comfort.

An extensive skin defect and necrotizing fasciitis derived from a neglected epidermal cyst on the upper back: A case report - Ovid.com
Article by Jae Hyun Kima, Jun Il Kima and Chan Min Chunga (Anyang-Si, Korea - Medicine). This case underscores the importance of not overlooking epidermal cysts and considering surgical intervention when they result in substantial skin and soft-tissue defects.

Triple-Shielded Microneedle Patch: A Synergistic Approach to Combat Infection, Oxidation and Inflammation in Wound Healing - PubMed
Abstract by Xingkai Ju, Jiao Kong, Erkang Wang, Shaojun Dong et al. (China - Small).

‘Bionic skin’ kills bacteria and cools temperature to speed up infected wound healing - Biotechniques.com
Article by Maddy Chapman. A bionic skin capable of passive cooling and on-demand antibacterial activity opens the door to the next generation of biomedical materials. Created by scientists from The Hong Kong Polytechnic University, the material closely mimics the mechanical properties and permeability of natural skin, demonstrating excellent healing when used to treat infected mouse wounds.

Scientists recruit the cell’s own waste system to heal diabetic wounds - Europa.eu
Article by Michael Allen. Diabetic foot ulcers can lead to serious health complications. EU-funded researchers have developed a new therapy to tackle the runaway inflammation that makes these wounds so hard to heal.

Comprehensive Review on Thermoplastic Polyurethane: Applications in Wound Healing and Smart Healthcare - Mdpi.com
Article by Karuppasamy Nandhini and Nae Yoon Lee (Seongnam-si, South Korea - Biomimetics). This review highlights the potential of TPU as a promising material for wound healing and numerous smart healthcare applications.

Film-forming sprays for wound healing: A critical review of iron chelator–antibiotic combination strategies - Sciencedirect.com
Article by Roshan Ramesh Kamble and Sarika Pranam Patil (Kolhapur, India - Next Nanotechnology). Iron chelator–antibiotic FFS represent a mechanistically rational, dual-functional wound care strategy. However, direct clinical evidence is absent. Systematic formulation development, in vivo validation in diabetic and biofilm-infected wound models, and dedicated safety and regulatory studies are required before clinical translation.

Innovative wound management of refractory venous ulcers with topical oxygen therapy - Sciencedirect.com
Article by Zachary E. Williams, Impreet Singh, Natalie Marks, Enrico Ascher and Anil P. Hingorani (New York, USA - Journal of Vascular Surgery: Venous and Lymphatic Disorders). Twenty of the 32 refractory venous leg ulcers (62.5%) treated with topical oxygen therapy either decreased in size or healed entirely after failing multiple previous therapies. Three of the 11 ulcers (27.3%) that healed completely recurred following topical oxygen therapy.

Neutrophil Extracellular Traps in Wound Healing of Diabetes: Mechanisms, Inducers, and Therapeutic Implications - Wiley.com
Article by Jiaojiao Xue, Zeyu Wang and Wenxiu (Jilin, China - Mediators of Inflammation). The authors explored promising clinical therapeutic strategies that promote healing by targeting neutrophil extracellular traps (NETs), such as DNase I degradation and inhibition of specific signaling pathways, highlighting the potential of NETs inhibition strategies in improving diabetic wound care.

A Promising Treatment of Keloids with Intralesional Bleomycin and Lidocaine - Saspublishers.com
Article by K. Youss, H. Sobhi, O. Baladi, H. El Yazidi et al. (Casablanca, Morocco - SAS Journal of Surgery). The clinical findings compared to those of various studies suggest that using a mixture of Bleomycin and Lidocaine leads to better success rate with fewer pain. Further investigations are needed to have a solid scientific support of this theory.

Bionic cooling skin for infected wound healing - Eurekalert.org
This work establishes a new paradigm for intelligent wound management by demonstrating that structural biomimicry and functional material design can be seamlessly integrated. The bionic cooling skin not only advances our understanding of wound repair mechanisms through multi-omics analysis but also holds significant promise for next-generation biomedical materials combining thermal comfort, active infection control, and accelerated tissue regeneration.

Castanea sativa Flower Extract Accelerates Burn Wound Healing via Antioxidant and Anti-Inflammatory Mechanisms in Juvenile Rats - Mdpi.com
Article by Şeyma Şimşirgil Kara, Özhan Özcan, Bilge Bal Özkaptan, Özgür Korhan Tunçel et al. (Turkey - Pharmaceuticals). The authors' findings support C. sativa flower extract as a promising candidate for further preclinical and clinical investigation in pediatric burn management, supporting the ethnopharmacological relevance of this plant in traditional wound care practices; further safety and efficacy validation is required before clinical translation.

Innovative polysaccharide hydrogels offer new hope for healing wounds - PubMed
Functional hydrogels based on bioactive Traditional Chinese Medicine (TCM) polysaccharides that integrate traditional medical wisdom with modern biomedical engineering represent a highly promising platform for the development of next-generation, effective, and intelligent wound repair materials.

Economic Impact of Negative Pressure Wound Therapy With Instillation Compared With Standard Negative Pressure Wound Therapy and Gauze Dressing in Acute Traumatic Wounds - News-medical.net
Abstract by Dimas A Milcheski, Ashley W Collinsworth, Siobhan Lookess, Rafael A Santos Jr et al. (Brazil, USA - Int Wound J.).

Fibrin-Based Biomaterials in Wound Healing and Soft Tissue Regeneration: Biological Mechanisms and Clinical Applications - Mdpi.com
Article by Bogdan Mircea Măciuceanu Zărnescu, Elena-Theodora Moldoveanu, Adelina-Gabriela Niculescu, Alexandru Scafa Udriște et al. (Bucharest, Romania - Gels). Although significant limitations remain, including rapid degradation, variable mechanical strength, and the need for standardized manufacturing processes, recent advances in hybrid systems and biofabrication technologies suggest promising future potential for personalized regenerative therapies.

From Biomaterials to Biological State Engineering: Reframing Advanced Wound Dressings as Adaptive Therapeutic Interfaces in Translational Medicine - Mdpi.com
Article by Tomasz Urbanowicz, Judyta Cielecka-Piontek, Krzysztof J. Filipiak, Anna Witkowska et al. (Poland - Cells). Chronic wound persistence can be interpreted as the consequence of multiscale biological memory involving immune, stromal, metabolic, extracellular matrix, mechanical, and microbial networks.Current wound-care technologies can be organized within an evolutionary framework that progresses from passive dressings to adaptive therapeutic interfaces.

Design and Therapeutic Applications of Hydrogel Dressings in Diverse Wound Management - Acs.org
Article by Weiyi Kong, Yuying Zhang, Haiyan Liang and Huanxiang Yuan (Beijing, China - ACS Omega). This review summarizes the applications of hydrogels in various wound types over the past 4 years, covering clinical scenarios such as burns, bone repair, gastrointestinal wounds, full-thickness skin injuries, and diabetic wounds. It highlights the multifunctionality, biocompatibility, antimicrobial properties, and prohealing capabilities of hydrogels in wound treatment, offering innovative approaches and insights for diverse wound management.

Copper-Coordinated Hyaluronic Acid Hydrogels with Antibacterial and Anti-Inflammatory Activities - Mdpi.com
Article by Jiajie Chen, Haotian Huang, Yihan Wang, Ran Cheng et al. (China - Molecules). The hydrogel effectively inhibited the growth and biofilm formation of both E. coli and S. aureus, reduced the expression of TNF-α, IL-6, and IL-1β in LPS-stimulated macrophages, and promoted fibroblast migration, demonstrating its potential as a multifunctional wound dressing for the management of infected wounds.

Hydrogel Dressings - News-medical.net
Article by Liji Thomas. All recent research supports the active use of hydrogels for wound dressing in most types of wounds, as their use leads to the hydration and loosening of necrotic tissue, promoting its autolysis and debridement, and absorbs moderate amounts of sloughing discharge and exudate.

Chronic refractory ulcer caused by Edwardsiella tarda: a case report and literature review - PubMed
Abstract by Qingdan Gu, Da Ma, Yi Wu, Wenxuan Wu et al. (China - BMC Infect Dis.).

Effects of different negative pressure wound therapy modes on wound healing: a systematic review - Frontiersin.org
Article by Cuiyi Wang, Xing Liu, Yitao Zhou, Naqin Liu et al. (Zhejiang, China - Front. Med.). Due to substantial heterogeneity in wound types, parameter settings, outcome measures, and study designs, the available evidence remains insufficient to establish a definitive ranking among NPWT modes or to determine optimal treatment parameters.

Isolating 2 Connected Wounds With the Paste Cork Technique: A Case Study - PubMed
Abstract by Elizabeth Claire Stipek (Fort Worth, USA - J Wound Ostomy Continence Nurs.).

A Comparative Study to Evaluate the Effect of Negative Pressure Wound Therapy and 3% Hypertonic Saline Dressings in the Management of Diabetic Foot Ulcers - Cureus.com
Article by Manjesh K A, Ashwini Dutt, Nagarjun Nelluri, Sreedhar Rao Kota et al. (Hyderabad, India). NPWT demonstrated superior wound healing outcomes compared with 3% hypertonic saline dressing in patients with diabetic foot ulcers. The therapy resulted in enhanced wound contraction, reduced hospitalization, and improved clinical outcomes. The authors' findings support the use of NPWT as an effective treatment modality in the management of diabetic foot ulcers.

Patient Safety in Ulcer Management: Healthcare Professionals’ Experiences of Systemic Challenges Across Primary and Secondary Healthcare Settings - Mdpi.com
Article by Marcus Rosenburg, Ingrid Larsson, Petra Svedberg and Anna Gyberg (Halmstad, Sweden - Healthcare). The authors' findings of the present study illustrated how healthcare professionals are largely left alone in ulcer management. Challenges due to organisational structures posed patient safety risks, which were, to a large extent, mitigated by the professionals’ dedication to patient care. This study highlights the need for stronger structural support to complement individual competence in promoting safe and effective ulcer management. Patient safety should not depend solely on individual professionals, but on structured, organisation-level guidelines.

Comparative Wound Healing Processes in Plants and Animals: Bioinspired Strategies for Advancing Regenerative Medicine - Mdpi.com
Article by Fatemeh Najafi, Natália Aparecida de Paula, Filipe Rocha Lima, Marcio Fronza et al. (Ribeirão Preto, Brazil - IJMS). The authors' approach represents a hypothetical future strategy requiring extensive preclinical validation to strategies based on extracts, conditioned media, extracellular vesicles, or isolated bioactive compounds. This descriptive review establishes a conceptual foundation for future investigations in plant biology, wound healing, and regenerative medicine.

Plant-Based Hydrogel Achieves Wound Closure in 72 Hours - Technologynetworks.com
Researchers at the Terasaki Institute for Biomedical Innovation have developed an injectable hydrogel, a water-based gel material, made from silk proteins and a plant-derived compound. In laboratory tests, the material promoted complete wound closure within 72 hours, suggesting a potential new approach to minimally invasive soft tissue repair.