Hungarian Wound Care Society

Wound healing improvement by a multicomponent wound dressing of keratinocyte-imprinted polydimethylsiloxane substrate in a rabbit model - Nature.com
Article by Shima Alipour, Davoud Shams, Saeed Samani, Soheila Pourkhodadad et al. (Tehran, Iran - Scientific Reports). The authors' findings suggest that each treatment may have potential applications depending on the medical conditions, particularly in situations where cellular factors are limited.

Cold Atmospheric Plasma Therapy for Diabetic Foot Ulcers: A Systematic Review and Meta-Analysis of Randomised Controlled Trials - Sagepub.com
Abstract by Duda Matija, Damjanović Ivan, Crkvenac Gregorek Andrea, Vrkic Kirhmajer Majda and Robert Likic (Zagreb, Croatia - The International Journal of Lower Extremity Wounds).

Can Broad-Focused ESWT Help Heal DFUs? - Hmpgloballearningnetwork.com
Article by Richard Kaufman. If you are treating DFUs or chronic wounds in clinic, broad-focused shockwave should be a modality which you highly consider utilizing to improve epithelialization rates and help your patients achieve fast wound closure.

A type of immune cell could hold a key to preventing scar tissue buildup in wounds - Eurekalert.org
Researchers at the University of Arizona uncovered a previously unknown population of circulating immune cells that play a critical role in fibrosis, the buildup of scar tissue that can lead to organ failure and disfigurement. The findings, published in Nature Biomedical Engineering, add to the understanding of the healing process and could lead to new strategies for preventing or treating fibrosis.

Engineering an antibacterial gel-forming adhesive powder for emergency hemostasis and wound healing - Cell.com
Article by Kaiwen Zhang, Yongmiao Chen, Gang He, Yu Yang et al. (China, Singapore - Cell Reports Physical Science). The authors' findings highlight the potential of antibacterial gel-forming adhesive powder (SLC) as an advanced hemostat for lethal hemorrhage control, wound healing, and infection prevention.

Intelligent Biosensors Based on Hyaluronic Acid Hydrogels for Monitoring Chronic Wound Healing with the Involvement of Artificial Intelligence - Mdpi.com
Article by Antonia-Mihaela Nicolae, Mihaela Badea, Sandica Bucurica. Florina Rasaliu and Elena Mihaela Constantinescu (Romania - Biosensors). This review discusses the recent progress of hyaluronic acid hydrogel biosensors for long-term wound healing, evaluating their strengths, challenges, and potential future improvements.

Topical Ozone as an Adjuvant Therapy in Wound Management: An Integrative Review - Mdpi.com
Article by Cristina Barroso Pinto, Adelino Pinto, Manuela Barroso, Telma Coelho and Sandra Costa (Portugal - Nursing Riports). The available evidence indicates that ozone may represent promising adjuvant treatment for certain types of wounds; however, the quality and independence of the existing studies are limited, and the lack of standardized protocols as well as methodological variability restrict the generalizability of the findings.

Photobiomodulation in Wounds of Individuals With Diabetes: A Nonrandomized Pilot Study - Hmpgloballearningnetwork.com
Article by Beatriz Barbieri Bortolozo, Amanda Ramiro Gomes da Silva, Thais Paulino Prado, Bianca Campos Oliveira et al. (Brazil - Wounds). Application of photobiomodulation (PBM) at an intensity of 2 J/cm² once a week did not produce measurable changes in the cytokine gene expression. However, significant reduction in wound area and an improvement in tissue repair were observed in patients treated with PBM.

COVID-19 as a Contributing Factor in the Development of Volkmann Ischemic Contracture: A Case Report - Cureus.com
Article by Tomas Maciulaitis, Patricija Glovackaite and Mindaugas Minderis (Vilnius, Lithuania). This case illustrates how systemic factors such as COVID-19, diabetes, and neuropathy may obscure early diagnosis and allow ischemic injury to progress. COVID-19 should be viewed as a potential contributing factor rather than a definitive cause, given its known inflammatory and vascular effects. Heightened clinical suspicion, prompt differentiation from soft-tissue infection, and timely surgical intervention are essential to prevent irreversible functional impairment.

Strategies for Incorporating Natural Therapeutic Agents into Hydrogel Dressings: Innovations in Wound Healing - Mdpi.com
Article by Cosmin Călina, Anca Scărișoreanu, Maria Demeter, Elena Mănăilă and Gabriela Crăciun (Măgurele, Romania - Polymers). Bioactive hydrogels incorporating standardized or nano-encapsulated natural extracts represent a new generation of multifunctional, non-pharmaceutic wound dressings that provide excellent biocompatibility and enhanced tissue regeneration in both acute and chronic wound healing.

What’s New (and What’s Next) in the 2025 International Pressure Injury Guideline - Woundsource.com
Article by Kirra Fedyszyn. While more guideline information continues to emerge, clinicians may consider using the 2019 CPG/QRG together with the published 2025 chapters to refresh their practices over the coming months. Interested parties may choose to bookmark the beta online guideline hub, and check back regularly as remaining chapters and tools go live.

Medical Device–Related Pressure Injury: What Wound Care Teams Need to Know - Woundsource.com
Article by Kirra Fedyszyn. Medical device-related pressure injury (MDRPI) is a distinct subset of pressure injury that occurs when a diagnostic or therapeutic device exerts sustained pressure or shear at the skin-device interface, often over bony prominences or along lines, tubing, masks, and collars. MDRPI prevention is the sum of small, reliable practices—seeing under devices, fitting them thoughtfully, protecting microclimate, and offloading whenever safely possible—delivered by teams working from shared protocols and data.

Omentin-1 promotes wound healing in diabetic mice by improving vascular endothelial cell function - Nature.com
Article by Yumeng Huang, Youjun Ding, Zhouji Ma, Ping Yang et al. (China - Scientific Reports). The authors' results suggest that omentin-1 is a potential adjunct or therapeutic agent for treating chronic non-healing diabetic wounds by enhancing endothelial cell function and promoting vascularization.

The Role of Cell Metabolism in Skin Wound Healing - Science.org
Article by Wenshuai Liu, Haiyue Jiang, Dongliang Yang and Yannan Xie (China - Research). Coordinated interactions between cells, extracellular matrices, and cytokines drive regeneration, while cell metabolism—an essential pillar of physiological activity—regulates key biological processes like proliferation, angiogenesis, immune responses, and tissue regeneration. Modulating metabolic pathways provides a promising alternative to conventional therapies.

Molecular Mechanisms of Wound Healing: The Role of Medicinal Plants - Mdpi.com
Article by Merlin Esad, Ivica Dimov, Mariya Choneva, Mihaela Popova et al. (Bulgaria, Germany - Life). Medicinal plants represent promising complementary approaches to wound management. Future research should focus on developing advanced drug delivery systems to enhance the stability, bioavailability, and targeted action of plant-derived compounds. Localized and biomaterial-based strategies show promise for sustained release at the wound site, and further preclinical and clinical studies are required to ensure their safety, reproducibility, and efficacy.

Cutaneous wound healing—insights from the matricellular perspective - Wiley.com
Article by Mariliis Klaas, Kristina Mäemets-Allas, Claudia Griselda Cárdenas-León and Viljar Jaks (Estonia - FEBSLetter). This review provides an update about the mechanisms by which matricellular proteins orchestrate the wound healing process.

Comparative Efficacy of Negative Pressure Wound Therapy and Conventional Treatments in the Management of Diabetic Foot Ulcers: A Systematic Review and Meta-Analysis - Mdpi.com
Article by Celia Villalba-Aguilar, José Alberto Laredo-Aguilera, Lucía Villalba-Aguilar, Matilde Isabel Castillo-Hermoso et al. (Spain - JCM). Although no significant differences were found in amputations or infections, this therapy reduces pain and decreases the use of antibiotics and analgesics. Its use requires individual and expert assessment to maximize its benefits.

Scar Wars: A Review of Topical Scar Therapies - Jddonline.com
Article by Nikkia Zarabian, Mina Farah and Adam Friedman (Washington, USA - JDD). Despite the substantial volume of research on scar management, many studies analyze the same primary data or produce inconclusive or contradictory results, complicating the development of standardized guidelines. This review evaluates the efficacy of topical silicone products, retinoids, pressure therapy, corticosteroids, and cannabinoids.

Hyaluronan-Based Hybrid Systems as Growth Factor Carriers in the Treatment of Chronic Wounds - Mdpi.com
Article by Aneta Ostróżka-Cieślik, Archana Tanwar and Monika Michalak (Poland, India - IJMS). The VEGF-containing dressing stimulated vascularisation and the production of collagen type-1 and fibronectin. Only one clinical study conducted in this field indicates the need for further research in this area.

Negative pressure wound therapy versus usual care in patients with surgical wound healing by secondary intention in the UK (SWHSI-2): an open-label, multicentre, parallel-group, randomised controlled trial - Nih.gov
Article by Catherine Arundel, Laura Mandefield, Caroline Fairhurst, Kalpita Baird et al. (UK - Lancet). In patients with a lower limb SWHSI, including those with complications of diabetes, there is no clear evidence that NPWT reduced the time to wound healing compared with standard dressings. These findings do not support the use of NPWT to augment SWHSI healing.

Efficacy and Safety of Negative Pressure Wound Therapy in Diabetic Foot Ulcers: A Cross-Sectional Analysis of Overlapping Meta-Analyses - Dovepress.com
Article by Ying Du, Tiangang Zhai, Zhujun Sheng, Weinan Xie et al. (Beijing, China - Diabetes, Metabolic Syndrome and Obesity). The highest-quality evidence, harmonized through this appraisal, confirms that NPWT is a safe and effective adjunctive therapy for DFUs. Its demonstrated ability to accelerate healing while reducing amputations provides a strong evidence base for consideration as a key component of standard clinical practice.

Reversing Fibrosis: New Research Provides Insight for Novel Therapies - Yale.edu
Article by Isabella Backman. Yale School of Medicine (YSM) researchers have made key breakthroughs in understanding how to treat fibrotic diseases such as scleroderma and graft-versus-host disease. Fibrotic diseases are a group of conditions—often autoimmune—characterized by excessive tissue scarring. They can drastically hinder patients’ quality of life, and in some cases, they can be life-threatening—fibrosis contributes to approximately 45% of all deaths in developed nations. However, there are no effective treatments.

Unlocking the Potential of Negative Pressure Wound Therapy in Diabetic Foot Ulcers: A Systematic Review and Meta-Analysis - Cureus.com
Article by Roshan A. Kadavan, Nikhil Deans, Rithin Punnackal Joseph, Jisna Vincent et al. (India). This systematic review and meta-analysis confirm the effectiveness of NPWT in improving wound closure, accelerating recovery, and reducing amputation rates in patients with DFUs.

Smart dressings and stem cells: The future of wound healing - Newatlas.com
Article by Paul McClure. Researchers from National Taiwan University (NTU) have led a review of recent research into advanced wound-healing technologies published over the last decade. Drawing data from clinical trials, animal studies, and lab experiments that explored new materials, biological agents, and smart delivery systems, the researchers compared these next-gen approaches to conventional dressing and therapies.

Hyaluronan-Based Hybrid Systems as Growth Factor Carriers in the Treatment of Chronic Wounds - Mdpi.com
Article by Aneta Ostróżka-Cieślik, Archana Tanwar and Monika Michalak (Poland, India - IJMS). Such dressings have shown good application prospects and are a promising tool in the treatment of chronic wounds. In the future, clinical trials should be conducted to confirm the observed effects and investigate the mechanisms of action.

Hyperbaric oxygen therapy to promote wound healing in severe pancytopenia: a case report - Magnonlinelibrary.com
Abstract by Connor Ta Brenna, Shawn Khan, Michael MacDougall, Jordan Tarshis et al. (Toronto, Canada - J Wound Care).

In Vitro, In Vivo, and Clinical Trial Approaches to Investigate the Effects of Medicinal Plants on Burn Wound Healing: A Systematic Review - Wiley.com
Article by Mahdi Bagheri, Seyed Mohammad Zarei, Mostafa Soodmand, Hossein Mardani Nafchi and Mir Hossein Hashemi Poor (Iran - International Wound Journal). Various medicinal plants discussed in this review improve the burn wound healing process due to the presence of diverse biological compounds with antioxidant, anti-inflammatory and antibacterial properties. These plants affect the four phases of wound healing. These plant species and their compounds could be potentially used for the development of effective natural remedies against burn wounds.

Protein linked to cancer plays key role in wound healing - News-medical.net
When doctors detect elevated levels of SerpinB3 in a blood test, it can signal that something is seriously wrong, from hard-to-treat cancers to severe inflammatory conditions. SerpinB3 is a critical protein that often reveals when the body's barrier tissues, like the skin or lungs, are under serious stress from cancer or chronic illness.

Postoperative Wound Care Practices of Acute Care Nurses: An Integrative Review - Wiley.com
Article by Gayani Priyangika Gamage, Josephine Lovegrove, Sanjeewa Seneviratne, Georgia Tobiano and Brigid Gillespie (Australia, Sri Lanka - International Wound Journal). This integrative review highlights that acute care nurses predominantly focused on technical dressing procedures with limited emphasis on comprehensive assessment, documentation, nutrition and patient education. Therefore, adopting a more holistic approach in surgical wound care could minimize practice variations among nurses.

Silicone-based fluid gel versus white paraffin ointment in the treatment of post-fractional ablative CO2 laser wound: an intra-individual split-face comparative study - PubMed
Abstract by Abdulmajeed Alajlan, Sadan AlHarbi, Khalid Nabil Nagshabandi, Ahmed Alajlan et al. (Saudi Arabia - J Dermatolog Treat.).

Next-Generation Wound Care: Guiding the Body to Heal Itself - Asiaresearch.com
Researchers at National Taiwan University have discovered how light, electricity, and tiny forces can work together to help wounds heal naturally and leave fewer scars, offering new hope for chronic wound care.

Smart hydrogel mimics skin repair to accelerate diabetic wound healing - Eurekalert.com
Researchers develop a bioinspired composite hydrogel that integrates antibacterial, immunomodulatory, and regenerative functions for chronic wound care.

Development and Characterization of a Wound-Healing System Based on a Marine Biopolymer -Mdpi.com
Article by Catalina Natalia Cheaburu Yilmaz, Melisa Sirin Yildirim, Defne Govem, Hulya Ayar Kayali and Onur Yilmaz (Izmir, Turkey - Gels). The formulated hydrogels exhibited significant swelling capacity, antioxidant activity, and the selected optimal formulation exhibited enhanced wound closure rates in vitro, demonstrating potential for wound-healing applications.

In Vitro Analysis of the Dynamic Role of the Bacterial Virulence Factors in Skin Wound Healing - Mdpi.com
Article by Ayat S Hammad, Sarah H. Zahedy, Shatha S. Elqasass, Sawsan Sudqi Said et al. (Qatar, Jordan - IJMS). The authors' findings highlight that bacterial virulence factors have variable impacts on acute wound healing.

Effectiveness of Negative Pressure Wound Therapy and Advanced Interventions in Preventing Surgical Site Infections: A Systematic Review - Cureus.com
Article by Muaz Hassan, Mohamed Eltayeb Abdelrahman Naiem, Moustafa U. Abdelradi, Rasha Omer Babiker Mohamed et al. (UK, Sudan). The effectiveness of NPWT and advanced wound interventions in preventing SSIs is not universal but is contingent on the specific surgical context. These technologies should be applied selectively, targeting patient populations and procedures where a clear benefit has been demonstrated, rather than being used routinely.

Wound Healing: Harnessing Extracellular Vesicles Derived from Adipose-Derived Stem Cells - Dovepress.com
Article by Qisong Liu, Cuiping Zhang, Yujie Liang and Xiaohua Pan (China - International Journal of Nanomedicine). Chronic wounds present a significant clinical challenge, placing a heavy burden on patients and highlighting the need for more effective treatments. Among emerging strategies, adipose-derived stem cells and their extracellular vesicles show great promise due to their potent wound-healing capabilities.