3D bioprinting and Rigenera® micrografting technology: A possible countermeasure for wound healing in spaceflight - Frontiersin.org
Article by Flaminia Aliberti, Elisa Paolin, Laura Benedetti, Gabriella Cusella and Gabriele Ceccarelli (Italy - Front. Bioeng. Biotechnol.).
This article discusses forthcoming experiments required under gravity and µG conditions to ensure effective and successful medical treatments for astronauts during long-term space missions, where healthcare is difficult and not guaranteed.
Silver Nanoparticles and Its Mechanistic Insight for Chronic Wound Healing: Review on Recent Progress - Mdpi.com
Article by Manoj Singh,Vanita Thakur, Vikas Kumar, Mayank Raj, Shivani Gupta, Nisha Devi, Sushil Kumar Upadhyay, Markéta Macho, Avik Banerjee, Daniela Ewe and Kumar Saurav (India, Czech Republic - Molecules).
In the current review, a brief introduction on traditional would healing approach is provided, followed by focus on the potential of wound dressing therapeutic techniques functionalized with Ag-NPs.
Severe Intermittent Hypoxia Modulates the Macrophage Phenotype and Impairs Wound Healing Through Downregulation of HIF-2α - Dovepress.com
Article by Lihong Chen, Yunyi Gao, Yan Li, Chun Wang, Dawei Chen, Yun Gao and Xingwu Ran (China - Nature and Science of Sleep).
Severe intermittent hypoxia could lead to M1 but not M2 macrophage polarization through downregulation of HIF-2α, and then lead to impaired wound healing.
Wound management and healing in space - Frontiersin.org
Article by Christopher Puhl, Nicol Caplin, Anna Fogtman and Angelique Van Ombergen (Netherlands, Germany - Front. Bioeng. Biotechnol.)
The space environment comes with environmental conditions (such as microgravity and ionising radiation) and several constraints in terms of available medical care. Previous studies have already shown that wound healing is slowed down and impaired in space due to the unloading related to the microgravity environment.
Predictors for limb amputation and reconstructive management in electrical injuries - PubMed
Abstract by Nadine Pedrazzi, Holger Klein, Tony Gentzsch, Bong-Sung Kim, Matthias Waldner, Pietro Giovanoli, Jan Plock and Riccardo Schweizer (Switzerland, Burns).
Soft tissue reconstruction of complex infra-inguinal wounds following revisionary vascular surgery - PubMed
Abstract by J-Frederick Hernekamp, Henrik Lauer, Ole Goertz, Ernst Weigang, Ulrich Kneser and Thomas Kremer (Germany - Ann Vasc Surg.).
The importance of periwound skin in wound healing: an overview of the evidence - PubMed
Abstract by Mark G Rippon, Alan A Rogers, Karen Ousey, Leanne Atkin and Kate Williams (UK, Australia, Ireland - J Wound Care).
Developing a Healing Formulation Able to Prevent Scar Hypertrophy - Journaljpri.com
Article by Patrizia Nardini, Matteo Urru and Alberto Chiarugi (Florence, Italy - Journal of Pharmaceutical Research International).
The present study, on the one hand indicates that the MHF may be harnessed to prevent the evolution of the healing process toward scar hypertrophy or keloids in patients, and on the other that a multicomponent strategy is a rational approach to developing topical remedies to prevent abnormal wound healing.
Ghrelin and leptin regulating wound healing -PubMed
Abstract by Guido Kroemer and Laurence Zitvogel (France - Trends Immunol.).
Air-Pressure-Supported Application of Cultured Human Keratinocytes in a Fibrin Sealant Suspension as a Potential Clinical Tool for Large-Scale Wounds - Dovepress.com
Article by Celena A. Sörgel, Rafael Schmid, Annika Kengelbach-Weigand, Theresa Promny and Raymund E. Horch (Erlangen, Germany - JCM).
The authors' findings indicate that the sprayed keratinocytes are superior to the application of the cells as droplets. The sprayed application may offer a promising therapeutic option in the treatment of large chronic wounds.
Possible clinical implications and future directions of managing bacterial biofilms in cutaneous leishmaniasis wounds - Springer.com
Article by T. D. Jayasena Kaluarachchi, Paul M. Campbell, Renu Wickremasinghe, Shalindra Ranasinghe, Surangi Yasewardene, Hiromel De Silva, Andrew J. McBain and Manjula Weerasekera (Sri Lanka, UK - Tropical Medicine and Health).
The authors highlight the importance of investigating the role of biofilms in cutaneous leishmaniasis wound healing, clinical indicators, cost-effective laboratory tests involving less invasive sampling techniques for diagnosing biofilms and potential therapeutic options for biofilm-containing CL wounds, such as adjunctive application of wound debridement and antimicrobial treatment along with anti-parasitic drugs.
A dopamine-methacrylated hyaluronic acid hydrogel as an effective carrier for stem cells in skin regeneration therapy - Nature.com
Article by Meihua Gong, Fei Yan, Li Yu and Furong Li (Shenzhen, China - Cell Death & Disease).
The DA-MeHA hydrogel may be used as an effective potential carrier for stem cells as it enhances the efficacy of ADSCs in skin regeneration.
Chitosan/Sodium Alginate/Velvet Antler Blood Peptides Hydrogel Promotes Diabetic Wound Healing via Regulating Angiogenesis, Inflammatory Response and Skin Flora - Dovepress.com
Article by Mingqian Hao, Chuanbo Ding, Shuwen Sun, Xiaojuan Peng and Wencong Liu (Changchun, China - Journal of Inflammation Research).
The authors' results indicate that CAVBPH is a promising wound dressing, and its repair effect on diabetic wounds by regulating angiogenesis, inflammatory response, and skin flora may depend on the rich small peptides in VBPs.
Molecular basis of clot retraction and its role in wound healing - PubMed
Abstract by Alan T. Nurden (Pessac, France - Thromb Res.).
Factors Associated With Perioperative Hospital Acquired Pressure Injury in Patients Undergoing Spine Surgery in the Prone Position: A Prospective Observational Study - PubMed
Abstract by Seungeun Choi, Yoon Jung Kim, Hyongmin Oh, Woon Tak Yuh, Chang-Hyun Lee, Seung Heon Yang, Chi Heon Kim, Chun Kee Chung and Hee-Pyoung Park (Seoul, Korea - J Neurosurg Anesthesiol.).
A single arm prospective feasibility study evaluating wound closure with a unique wearable device that provides intermittent plantar compression and offloading in the treatment of non-healing diabetic foot ulcers - Wiley.com
Article by David G. Armstrong, Dennis P. Orgill, Paul M. Glat, Robert D. Galiano, Zachary L Rasor, Adam Isaac, Marissa Carter and Charles M. Zelen (USA - International Wound Journal).
This unique intermediate plantar compression and offloading device may be considered as an alternative for safe and effective for treatment of non-healing diabetic foot ulcers. During treatment, wound healing was significantly accelerated, and pain was improved.
Why Does Skin Itch When Healing? - Verywellhealth.com
Article by Kelly Burch.
Whether you scrape your knee, cut yourself, or are recovering from surgery, you might experience the same annoying side effect: itching around your wound. So why does skin itch while healing? Scientists are still investigating, but it's believed that as the skin heals, it stimulates nerve cells that can leave you feeling itchy.
Effectiveness of Injected Platelet-Rich Plasma in the Treatment of Diabetic Foot Ulcer Disease - Cureus.com
Article by Asad Ullah, Syed I. Jawaid, Pir Naveed Ahmed Ahsan Qureshi, Tehreem Siddiqui, Khadija Nasim, Kantash Kumar, Shafqat Ullah, Mustafa Sajjad Cheema, Nikita Kumari and Hafiza Azad Elias.
The study concluded that injected PRP was significantly better than conventional dressing in the management of diabetic foot ulcer. More clinical trials are necessary to evaluate the effectiveness of injected PRP to validate the current findings.
A Comprehensive Review of Natural Compounds for Wound Healing: Targeting Bioactivity Perspective - Mdpi.com
Article by Xuan-Tung Trinh, Nguyen-Van Long, Le Thi Van Anh, Pham Thi Nga, Nguyen Ngan Giang, Pham Ngoc Chien, Sun-Young Nam and Chan-Yeong Heo (Korea - IJMS).
In this work, the authors provide a comprehensive review of natural compounds sourced from both plants and animals that target the different bioactivities of healing to promote wound resolution.
Utilization of a topical autologous blood clot for treatment of pressure ulcers - Wiley.com
Article by Zvi Landau, Katie Lyn Whitacre, Charles Leewood, Jessie Hawkins and Chinenye D. Wachuku (Israel, USA - International Wound Journal).
The potential of bringing an affordable, cost-effective, advanced biologic bedside treatment that is efficacious in resolution of these complex wounds has the potential to drastically reduce the burden of treatment on the health system.
Extraction, Characterization, and Structure of a Novel Heteropolysaccharide from Lepidium sativum and Its Effects on Wound Healing in Diabetic Rats - Hindawi.com
Article by Sirine Ben Slima, Naourez Ktari, Aicha Chouikhi, Amina Hzami, Sana Bardaa, Imen Trabelsi, Basma Ben Salah and Riadh Ben Salah (Tunisia - BioMed Research International).
The authors' results strongly support the beneficial effects of the PLS to accelerate wound healing in diabetic rats.
Sequential Wound Therapy and Negative Pressure Wound Therapy - Consultant360.com
In this podcast, Robert Klein, DPM, CWS, speaks about the effects of negative pressure wound therapy on wound healing, new technologies and treatment approaches, and what primary care providers and emergency medical physicians should know about negative pressure wound therapy.
Biosynthesis of silver nanoparticles with antibacterial, antioxidant, anti-inflammatory properties and their burn wound healing efficacy - Frontiersin.org
Article by Bum-Erdene Bold, Enerelt Urnukhsaikhan and Tsogbadrakh Mishig-Ochir (Ulaanbaatar, Mongolia - Front. Chem.).
The current study aims to develop a novel burn wound ointment consisting of sheep’s tail ointment loaded with AgNP. The AgNP in the ointment serves as an antibacterial, antioxidant and anti-inflammatory agent.
Oxygenation therapies for improved wound healing: Current trends and technologies - Rsc.org
Abstract by Garima Malik, Tarun Agarwal, Marco Costantini, Sampriti Pal and Arun Kumar (Journal of Materials Chemistry B).
Do Wounds Heal Faster in a Caloric Surplus? - Healthline.com
Whenever you get a wound, your body works hard to heal it as quickly as possible. During wound healing, your body relies on calories and nutrients to repair and rebuild damaged tissue. This may have you wondering whether you should make adjustments to your diet, such as eating more calories, to help a wound heal faster.
The Issue of Noncompliance in Wound Care Patients: Part 2: Strategies for Wound Care Clinicians - Woundsource.com
Article by Dianne Rudolph.
Managing a patient with a complex or chronic wound is a challenge in itself and can be made more complicated when there are issues of non-adherence at stake. Educating the patient, setting boundaries when appropriate, and documenting thoroughly are critical elements.
Creating a Plan of Care for Wound Management - Woundsource.com
Wound management is a tremendous clinical challenge for many health care professionals. The World Health Organization has recognized that wound management is a worldwide public health issue best managed by an interprofessional team. This interdisciplinary approach has been shown to increase healing and decrease wound recurrence. However, it requires shared decision making with many clinicians to create an optimal care plan.
Medical Malpractice Litigation: Standards of Care - Woundsource.com
Article by Heidi Cross.
In medical malpractice litigation, a thorough review of the medical chart is done to determine whether the facility or health care provider “met the standards of care” related to the medical issues at hand in the complaint.
The impact of a clinical prediction tool (BuRN-Tool) for child maltreatment on social care outcomes for children attending hospital with a burn or scald injury - PubMed
Abstract by C Verity Bennett, Linda Hollén, David Wilkins, Alan Emond and Alison Kemp (Cardiff, UK - Burns):
Application of an instructive hydrogel accelerates re-epithelialization of xenografted human skin wounds - Nature.com
Article by Holly D. Sparks, Serena Mandla, Katrina Vizely, Nicole Rosin, Milica Radisic and Jeff Biernaskie (Canada - Scientific Reports).
The authors' data provide strong evidence that topical application of QHREDGS peptide-modified hydrogels results in accelerated wound closure that may lead to improved outcomes for patients.
The effectiveness of drugs combined with individualised management for elderly patients with stage III pressure ulcers - PubMed
Abstract by Rui Shao, TingTing Du, YongQiang Zhang, Yan Li and Qiang Zhang (Tianjin, China - J Cosmet Dermatol.).
The influence zone: a critical performance measure for negative pressure wound therapy systems - PubMed
Abstract by Amit Gefen (Tel Aviv, Israel - Br J Nurs.).
The Role of Cannabinoids in Wound Management - Lww.com
In this videocast, Dr Christopher Barrett interviews Dr Pritesh Kumar about exciting recent developments in harnessing the power of the endocannabinoid system for wound healing. Read the related article, “Evidence-based Potential Therapeutic Applications of Cannabinoids in Wound Management” in the September 2022 issue of Advances in Skin & Wound Care.
A Granulation Tissue Detection Model to Track Chronic Wound Healing in DM Foot Ulcers - Mdpi.com
Article by Angela Shin-Yu Lien, Chen-Yao Lai, Jyh-Da Wei, Hui-Mei Yang, Jiun-Ting Yeh and Hao-Chih Tai (Taiwan - Electronics).
The preliminary findings may help to identify the granulation tissue of patients with DM foot ulcer, which may lead to better long-term home care during the COVID-19 pandemic.
A self-healing hydrogel based on crosslinked hyaluronic acid and chitosan to facilitate diabetic wound healing - PubMed
Abstract by Ziqiang Zhou, Xuejuan Zhang, Lijun Xu, Huangjie Lu, Yuying Chen, Chuanbin Wu and Ping Hu (Guangzhou, China - Int J Biol Macromol.).
Overview of Venous Ulcers - Verywellhealth.com
Article by Brandi Jones.
Venous ulcers are shallow wounds or sores caused by circulation or blood flow problems. They typically occur over a bony area of the leg such as the ankle. Circulation problems result from leg veins that don't push blood back towards the heart, called venous insufficiency.
Murine macrophages or their secretome delivered in alginate dressings enhance impaired wound healing in diabetic mice - PubMed
Abstract by Georgios Theocharidis, Sahar Rahmani, Sangmin Lee, Zhuqing Li, Antonio Lobao, Konstantinos Kounas, Xanthi-Lida Katopodi, Peng Wang, Salina Moon, Ioannis S Vlachos, Monika Niewczas, David Mooney and Aristidis Veves (USA - Biomaterials).
Addressing the Socioemotional Aspects of Chronic Venous Leg Ulcerations (CVLUs) - Woundsource.com
Article by Christine Miller.
Chronic venous leg ulcers (CVLUs) are one of the most common lower extremity wounds with a recurrence rate of as high as 70%. While there has been tremendous progress in treating venous insufficiency from a surgical perspective along with advanced wound healing techniques, CVLUs are still a major hurdle to overcome.
Peristomal Skin Conditions: Pyoderma Gangrenosum - Woundsource.com
Article by Holly Hovan.
Peristomal pyoderma gangrenosum (PPG) is a neutrophilic dermatosis characterized by painful ulcers which can be recurrent and is often associated with systemic diseases such as inflammatory bowel disease (IBD), arthritis, or hematologic disorders.
The effect of sub-epidermal moisture on pressure injury prevention strategies and incidence of pressure injuries: A feasibility pilot randomised controlled trial - PubMed
Abstract by Jill Campbell, Wendy Chaboyer, Georgia Tobiano, Emma Harbeck, Tracy Nowicki, Zena Moore, Gary Allen, Brigid Gillespie, Fiona Coyer and Rachel Walker (Australia - J Tissue Viability).
Borrowing the Features of Biopolymers for Emerging Wound Healing Dressings: A Review - Mdpi.com
Article by Ioannis Gardikiotis, Florina-Daniela Cojocaru, Cosmin-Teodor Mihai, Vera Balan and Gianina Dodi (Iasi, Romania - IJMS).
This article provides an overview of biopolymers’ roles in wound physiology as a perspective on the development of a new generation of enhanced, naturally inspired, smart wound dressings based on blood products, stem cells and growth factors.
An in vivo critically colonised wound model with dysbiotic wound microbiota - Wiley.com
Article by Mao Kunimitsu, Gojiro Nakagami, Takeo Minematsu, Sofoklis Koudounas and Hiromi Sanada (Japan - International Wound Journal).
This is the first study to develop a novel animal model that represents the clinical features of critically colonised wounds and will be useful in investigating the pathogenesis of critical colonisation via regulatory T cells.
Microbial Interplay in Skin and Chronic Wounds - Springer.com
Article by Chandni Sachdeva, Kapaettu Satyamoorthy and Thokur Sreepathy Murali (Manipal, India - Current Clinical Microbiology Reports).
In this review, the authors discuss biomarkers associated with chronic wound microenvironment along with the relevance of skin microflora and their metabolites in determining the chronicity of wounds.
Innovative Treatment Strategies to Accelerate Wound Healing: Trajectory and Recent Advancements - Mdpi.com
Article by Praveen Kolimi, Sagar Narala, Dinesh Nyavanandi, Ahmed Adel Ali Youssef and Narendar Dudhipala (USA, Egypt - Cells).
The main objective of this review is to provide an updated overview of progress in therapeutic options in chronic wounds healing and management over the years using next generation innovative approaches. Herein, the authors have discussed the skin function and anatomy, wounds and wound healing processes, followed by conventional treatment modalities for wound healing and skin regeneration.
Fibroblasts: Immunomodulatory factors in refractory diabetic wound healing - Frontiersin.org
Article by Ye Liu, Yiqiu Liu, Wenjie He, Xingrui Mu, Xingqian Wu, Junyu Deng and Xuqiang Nie (Zunyi, China - Front. Immunol.).
By exploring the heterogeneity and functional changes of fibroblasts in diabetes, the manuscript discusses that fibroblasts may be used as immunomodulatory factors in refractory diabetic wound healing, providing new ideas for the treatment of refractory diabetic wound healing.
Hydrogel dressings for venous leg ulcer - PubMed
Abstract by Cibele Td Ribeiro, Fernando Al Dias and Guilherme Af Fregonezi (Brazil - Cochrane Database Syst Rev.).
Wound healing in aged skin exhibits systems-level alterations in cellular composition and cell-cell communication - Cell.com
Article by Remy Vu, Suoqin Jin, Peng Sun, Daniel Haensel, Quy Hoa Nguyen, Morgan Dragan, Kai Kessenbrock, Qing Nie and Xing Dai (Stanford, USA - Cell Reports).
The authors' study exposes numerous cellular/molecular targets for functional interrogation and provides a hypothesis-generating resource for future wound healing studies.
The effectiveness of vacuum-assisted closure therapy in patients with infected venous leg ulcers - PubMed
Abstract by Esra Ertürk Tekin, Mehmet Ali Yeşiltaş, Ayhan Uysal and İsmail Haberal (Turkey - Cardiovasc J Afr.).
DPSC Products Accelerate Wound Healing in Diabetic Mice through Induction of SMAD Molecules - Mdpi.com
Article by Carl J. Greene, Sarah Anderson, Derek Barthels, Md Sariful Islam Howlader, Suman Kanji, Jaganmay Sarkar and Hiranmoy Das (Amarillo, USA - Cells).
The authors defined the cellular and molecular mechanisms by which DPSC products accelerated diabetic wound closure, which can be used to treat diabetic wounds in the near future.
Clinical efficacy of wet dressing combined with chitosan wound dressing in the treatment of deep second-degree burn wounds: A prospective, randomised, single-blind, positive control clinical trial - Wiley.com
Article by Jialin Hu, Yuesen Lin, Chengshuo Cui, Fangfang Zhang, Tingting Su, Kaiyu Guo and Tiannan Chen.
Chitosan wound dressing can significantly shorten the time of wound healing and reduce wound pain and wound infection in patients with deep second-degree burns. And it can effectively improve the situation of scar hyperplasia, which is worthy of clinical application.
Antioxidant Silk Fibroin Composite Hydrogel for Rapid Healing of Diabetic Wound - PubMed
Abstract by Biswanath Maity, Shadab Alam, Sourav Samanta, Relekar G Prakash and Thimmaiah Govindaraju (Bengaluru, India - Macromol Biosci.).
Wound Healing Impairment in Type 2 Diabetes Model of Leptin-Deficient Mice – A Mechanistic Systematic Review - Mdpi.com
Article by Albert Stachura, Ishani Khanna, Piotr Krysiak, Wiktor Paskal and Paweł Włodarski (Warsaw, Poland - IJMS).
Some studies investigated novel chronic diabetes wound models, based on a leptin-deficient murine model, which was also described. The authors also discussed the interventions studied in vivo, which passed into human clinical trials. It is their hope that this review will help plan future research.
A systematic review of movement monitoring devices to aid the prediction of pressure ulcers in at-risk adults - PubMed
Abstract by Zena Moore, Pinar Avsar, Tom O'Connor, Aglecia Budri, Dan L Bader, Peter Worsley, Silvia Caggiari and Declan Patton (Ireland, Saudi Arabia, Belgium, China, UK, Australia - Int Wound J.).
Implant salvage in patients with severe post-fracture fixation surgical site infection using negative pressure wound therapy with intramedullary and subcutaneous antibiotic perfusion - PubMed
Abstract by Keisuke Shimbo, Tatsuhiko Saiki, Haruka Kawamoto and Isao Koshima (Hiroshima, Japan - Wounds).
Biofilm-Based Wound Management: Implications for Clinical Practice - Hmpgloballearningnetwork.com
Biofilm is known to be present in most, if not all, chronic and hard-to-heal wounds. It usually cannot be seen by the naked eye, so its presence is presumed. Disrupting biofilm is an important component in any wound treatment strategy. Because biofilm is associated with delayed wound healing, incorporating evidence-based anti-biofilm strategies into a proactive wound healing protocol of care that is delivered regularly and repeatedly can expedite wound healing and improve patient outcomes.
Chronic wounds: a clinical problem requiring ownership and coordination - Wiley.com
Article by Keith G. Harding (Cardiff, UK - British Journal of Dermatology).
This is a call to arms to ensure that in the 21st century we are more capable of dealing with a clinical challenge that is common, expensive and has substantial potential for improvement. It is anticipated that dermatologists, and multiple other medical specialities, would have a major role in driving these developments forward.
Times Quicker Burn Healing With Hyperbaric Oxygen Therapy - Newswire.net
Article by Gordana Velaja.
Burn injuries are not minor scars but have a lot of behind the scene damage. Therefore burn victims should be managed with special care.
Signaling Pathways Associated with Chronic Wound Progression: A Systems Biology Approach - Mdpi.com
Article by Proma Basu and Manuela Martins-Green (Riverside, USA - Antioxidants).
Experimental verification in vivo could identify candidates for treatment of chronic wounds.
Mechano-biological and bio-mechanical pathways in cutaneous wound healing - Biorxiv.org
Abstract by Marco Pensalfini and Adrian Buganza Tepole (West Lafayette, USA).
At-Risk Patient: Pressure Ulcers/Injuries - Woundsource.com
A patient at-risk of developing a pressure injury is an individual who has limitations in daily living activities that could result in chronic problems if exposed pressure, friction, shear, or moisture. Bed-ridden patients, especially those with spinal cord injuries, those who are hemodynamically unstable, the elderly, and the very young are primarily at risk of developing pressure injuries.
The Importance of Nutrition in Healing: Lessons Learned From Scurvy - Woundsource.com
Article by Christine Miller.
The role of nutrition in wound healing has been heavily explored since the early part of the 20th century. Addressing the proper balance of both macronutrients and micronutrients is a crucial part of the systemic treatment plan for patients with chronic wounds.
Clinical Evaluation of a Synthetic Hybrid-Scale Matrix in the Treatment of Lower Extremity Surgical Wounds - Cureus.com
Article by Daniel Tucker.
This retrospective case series demonstrates the versatility of synthetic hybrid-scale fiber matrices as part of an effective treatment regimen for difficult-to-treat lower extremity operative wounds.
Is Balding Unavoidable? New Research Suggests Not - Webmd.com
Article by Maya Davis.
New research from the University of California, Riverside suggests the cure for baldness resides in understanding just one thing: transforming growth factor beta (TGF-β). The study, published in the Biophysical Journal, identifies TGF-β – one of many small proteins called cytokines that help control other immune system cells and blood cells – as the moderator of the hair follicle growth cycle, determining when hair follicle cells grow and when they die.
Nanobiotechnology: Applications in Chronic Wound Healing - PubMed
Abstract by Tao Jiang, Qianyun Li, Jinmei Qiu, Jing Chen, Shuang Du, Xiang Xu, Zihan Wu, Xiaofan Yang, Zhenbing Chen and Tongkai Chen (China - Int J Nanomedicine).
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