The Value of Negative-Pressure Wound Therapy and Flap Surgery in Hidradenitis Suppurativa – A Single Center Analysis of Different Treatment Options - Frontiersin.org
Article by M. C. Stumpfe, R. E. Horch, A. Arkudas, A. Cai, W. Müller-Seubert, T. Hauck and I. Ludolph (Erlangen, Germany - Front. Surg.).
Radical excision of hidradenitis suppurativa as gold standard for surgical treatment combined with negative-pressure wound therapy as multi-stage procedures ultimately reduced bacterial load and flora in the authors' study. The use of split-thickness skin grafts showed the lowest recurrence rate.
In Vitro Wound Healing Properties of Novel Acidic Treatment Regimen in Enhancing Metabolic Activity and Migration of Skin Cells - Mdpi.com
Article by Pivian Sim, Yunmei Song, Gink N. Yang, Allison J. Cowin and Sanjay Garg (Adelaide, Australia - IJMS).
This in vitro study is the first to establish a correlation between the role of acidic pH, molarity and treatment regimen in cellular activity. The authors' data demonstrated a positive effect of acidic pH on cell metabolic activity and migration rate, suggesting a clinical potential in indications such as wound healing.
Natural Herbals and Spices in Wound Healing - Encyclopedia.pub
Herbal medicines have been employed in folk medicine to accelerate wound healing since ancient times. Many plants and various preparations thereof have been used traditionally in relation to wound treatment, especially due to their immense potential to affect wound healing. Plant-based extracts and/or isolates support tissue regeneration through a variety of mechanisms, which often work together to improve the whole healing process.
A deep-dive thematic analysis of low-harm hospital-acquired pressure ulcers - PubMed
Abstract by Jenni MacDonald (London, UK - Br J Nurs.).
A comparison of the epidemiology of isolated and non-isolated hand burns - PubMed
Abstract by Dallan Dargan, Ghita Himmi, Umair Anwar, Sharmila Jivan and Preetha Muthayya (Wakefield, UK - Burns).
Demonstration of elevated type I and type III procollagen mRNA levels in cutaneous wounds treated with helium-neon laser: Proposed mechanism for enhanced wound healing - Sciencedirect.com
Abstract by David Saperia, Edward Glassberg, Richard F. Lyons, R. Patrick Abergel, Philippe Baneux, John C. Castel, Richard M.Dwyer and Jouni Uitto (Torrance, USA - Biochemical and Biophysical Research Communications).
Colistimethate sodium-chitosan hydrogel for treating Gram-negative bacterial wound infection - PubMed
Abstract by Aathira Pradeep, Nivethitha Ashok, V Priya, Anoop V Pillai, Riju Ramachandran Menon, V Anil Kumar and R Jayakumar (Kochi, India - Int J Biol Macromol.).
Fibroblast Heterogeneity in Healthy and Wounded Skin - Cshlp.org
Article by Clarisse Ganier, Emanuel Rognoni, Georgina Goss, Magnus Lynch and Fiona M. Watt (London, UK - Cold Spring Harbor Laboratory Press).
The authors discuss the current state of knowledge regarding dermal fibroblast heterogeneity in healthy mouse and human skin, highlighting the similarities and differences between mouse and human fibroblast subpopulations. They also
discuss how fibroblast heterogeneity may provide insights into physiological wound healing and its dysfunction in pathological states such as hypertrophic and keloid scars.
The impact of nutrition on pressure ulcer healing - PubMed
Abstract by Sarah Manley and Aby Mitchell (London, UK - Br J Nurs.).
Use of Information Communication Technology Tools in Diabetic Foot Ulcers Prevention Programs: A Scoping Review - PubMed
Abstract by Helen Ngozichukwuka Obilor, Meshack Achore and Kevin Woo (Canada, Nigeria - Can J Diabetes).
Application of Negative Pressure Therapy on Skin Grafts after Soft-Tissue Reconstruction: A Prospective Observational Study - PubMed
Abstract by Aeshah Mandili, Abdullah Aljubairy, Bayan Alsharif, Wala Patwa, Khlood Alotibey, Sara Basha and Ziyad Alharbi (Saudi Arabia - Clin Pract.).
Hydrogel Combined with Phototherapy in Wound Healing - Wiley.com
Abstract by Yinglin Xu,Haolin Chen,Yifen Fang and Jun Wu (Advanced Health Material).
The Histologic Effects of Retention Sutures on Wound Healing in the Rat - Hmpgloballearningnetwork.com
Article by Jeffrey A. Ascherman, Valerie A. Jones and Sean L. Knowles.
Although retention sutures are commonly used as a prophylactic measure against abdominal dehiscence at surgical sites, caution is warranted in their use. The present study suggests that retention sutures increase the inflammatory response and localized infection incidence in postoperative wounds in the early stages of rat wound healing.
Scarless Skin Grafting Using Mussel Adhesive Protein - Scienceblog.com
The depth of scarring after suturing varies depending on the skill of the medical personnel performing the skin grafting, and wound healing at the suture site requires over a month. Recently, a Korean research team has drawn attention for developing a bioadhesive based on the mussel adhesive protein (MAP) that enables quick healing of wounds with minimum scarring.
Successful Treatment of Wound Dehiscence by Innovative Type 1 Collagen Flowable Gel: A Case Report - PubMed
Abstract by Giuseppe A Ferraro, Giuseppe Lanzano, Elisa Grella, Adelmo Gubitosi and Giovanni F Nicoletti (Naples, Italy - Plast Reconstr Surg Glob Open).
Proteoglycan 4 (PRG4) treatment enhances wound closure and tissue regeneration - Nature.com
Article by Roman J. Krawetz, Saleem Abubacker, Catherine Leonard, Anand O. Masson, Sophia Shah, Nadia Narendran, Pankaj Tailor, Suresh C. Regmi, Elodie Labit, Nicoletta Ninkovic, Jessica May Corpuz, Kenichi Ito, T. Michael Underhill, Paul T. Salo, Tannin A. Schmidt and Jeff A. Biernaskie (Canada, USA - npj Regenerative Medicine).
Using an ear wound model, topical application of exogenous recombinant human (rh)PRG4 hastened wound closure and enhanced tissue regeneration.
Evaluation of Melia azedarach extract-loaded poly (vinyl alcohol)/pectin hydrogel for burn wound healing - Plos.org
Article by Jun Seung Lee, Kyung Hoon Sun and Yongjin Park.
MAE was found to be effective against burn wounds and to have antimicrobial activity in vitro and in vivo.
Ultrasound scanning of post-operative wounds - the risks of cross-infection - Sciencedirect.com
Abstract by P. Spencer and R. C. Spencer (Sheffield, UK - Clinical Radiology).
Filamentous bacteriophage delays healing of Pseudomonas-infected wounds - PubMed
Abstract by Michelle S Bach, Christiaan R de Vries, Arya Khosravi, Johanna M Sweere, Medeea C Popescu, Qingquan Chen, Sally Demirdjian, Aviv Hargil, Jonas D Van Belleghem, Gernot Kaber, Maryam Hajfathalian, Elizabeth B Burgener, Dan Liu, Quynh-Lam Tran, Tejas Dharmaraj, Maria Birukova, Vivekananda Sunkari, Swathi Balaji, Nandini Ghosh, Shomita S Mathew-Steiner, Mohamed S El Masry, Sundeep G Keswani, Niaz Banaei, Laurence Nedelec, Chandan K Sen, Venita Chandra, Patrick R Secor, Gina A Suh and Paul L Bollyky (USA - Cell Rep Med.).
Immuno-activated mesenchymal stem cell living electrospun nanofibers for promoting diabetic wound repair - PubMed
Abstract by Shaoying Gao, Tao Chen, Zhen Wang, Ping Ji, Lin Xu, Wenguo Cui and Ying Wang (China - J Nanobiotechnology).
Support in Wound Care: National Organizations - Woundsource.com
Wound care is complex. Even professionals who have worked as wound care specialists for decades are still learning as researchers discover more about the healing process and barriers that impede healing. Additionally, the medical professionals who may work with a patient with a complex or chronic wound can include clinicians with varying expertise, such as nurses, physical therapists, surgeons, dietitians, and so on. Fortunately, several national organizations are committed to enhancing the quality of wound care for both wound care professionals and patients alike.
Tideglusib promotes wound healing in aged skin by activating PI3K/Akt pathway - Biomedcentral.com
Article by Jiachen Sun, Hongqing Zhao, Chuan’an Shen, Shiyi Li, Wen Zhang, Jinglong Ma, Zhisheng Li, Ming Zhang and Jianqiu Yang (Beijing, China - Stem Cell Research & Therapy).
Tideglusib could assist wound healing in aged rats via activating PI3K/Akt pathway, which may be considered as an ingredient for medical and cosmetics use.
A new strategy for the treatment of chronic wounds - Researchoutreach.org
Wound healing is highly regulated, but oxidative stress (OS) can disturb this healing process in chronic wounds. To better understand the process of initiating chronicity, Dr Manuela Martins-Green and her colleagues at the University of California investigated the impact of increased OS levels on wound healing by stimulating chronic wound development in a diabetic mouse model.
Measuring collagen injury depth for burn severity determination using polarization sensitive optical coherence tomography - Nature.com
Article by Taylor M. Cannon, Néstor Uribe-Patarroyo, Martin Villiger and Brett E. Bouma (USA - Scientific Reports).
The authors' methods, which they have validated ex vivo with matched histology, offer an information-rich tool for precise interrogation of burn wound severity and healing potential in both research and clinical settings.
Effectiveness of prophylactic application of negative pressure wound therapy in stopping surgical site wound problems for closed incisions in breast cancer surgery: A meta-analysis - PubMed
Abstract by Jingyong Song, Xia Liu and Tingting Wu (Haikou, China - Int Wound J.).
State-of-the-Art on Wound Vitality Evaluation: A Systematic Review - Mdpi.com
Article by Aniello Maiese, Alice Chiara Manetti, Naomi Iacoponi, Eleonora Mezzetti, Emanuela Turillazzi, Marco Di Paolo, Raffaele La Russa, Paola Frati and Vittorio Fineschi (Italy - IJMS).
This review aimed to collect all the knowledge on vital wound demonstration and provide a temporal distribution of the methods currently available, in order to determine the age of lesions, thus helping forensic pathologists in finding a way through the tangled jungle of wound vitality evaluation.
Cellular and Molecular Mechanisms of Oxidative Stress in Wound Healing - Hindawi.com
Article by Reggiani Vilela Gonçalves, Mariella Bontempo Freitas and Debora Esposito (Brazil, USA - Oxidative Medicine and Cellular Longevity).
Understanding the relationship between the interaction of these different mechanisms and the oxidative process is important to provide a
guideline for decision-makers in the choice of better treatments and consequently accelerate skin wound closure.
Limb Salvage with Multiple Modalities: A Case Report of a Diabetic Heel Ulcer Associated with Peripheral Arterial Disease - PubMed
Abstract by Kyoichi Matsuzaki and Akira Miyamoto (Japan - Adv Skin Wound Care).
Wounds Secondary to Sleeping Position Part 1: Recognizing Pressure Injuries Secondary to Sleeping Position - Woundsource.com
Article by Robin Lenz and Fahad Hussain.
Heel pressure injuries and various forms of ulcers are easy to identify, but are you overlooking sleeping position as a cause for wounds in other locations?
Foot complications in people with diabetes - Surgeryjournal.co.uk
Abstract by Ian Diebels and Robert J. Hinchliffe (Surgery).
Role of Inflammasomes in Keloids and Hypertrophic Scars - Lessons Learned from Chronic Diabetic Wounds and Skin Fibrosis - Mdpi.com
Article by Chenyu Huang and Rei Ogawa (China, Japan - IJMS).
Studies suggest that mechanical stimuli activate inflammasomes via the cytoskeleton and that mechanotransduction-inflammasome crosstalk is involved in fibrosis.
Transdermal deferoxamine administration improves excisional wound healing in chronically irradiated murine skin - PubMed
Abstract by Hendrik Lintel, Darren B Abbas, Christopher V Lavin, Michelle Griffin, Jason L Guo, Nicholas Guardino, Andrew Churukian, Geoffrey C Gurtner, Arash Momeni and Michael T Longaker, Derrick C Wan (USA - J Transl Med.).
Regenerative Approaches for Chronic Wounds - Annualreviews.org
Article by François Berthiaume and Henry C. Hsia (USA - Annual Review of Biomedical Engineering).
This article describes new experimental avenues for attempting to improve the regenerative response of skin using biophysical techniques as well as biochemical methods, in some cases by trying to harness the potential of stem cells, either endogenous to the host or provided exogenously, to regenerate the skin.
PAQR3 depletion accelerates diabetic wound healing by promoting angiogenesis through inhibiting STUB1-mediated PPARγ degradation - Nature.com
Article by Jian Qiu, Chang Shu, Xin Li and Wei-Chang Zhang (Changsha, China - Laboratory Investigation).
The authors' findings demonstrates that PAQR3 silencing accelerates diabetic wound healing by promoting M2 macrophage polarization and angiogenesis, which is mediated by the inhibition of STUB1-mediated PPARγ protein ubiquitination and degradation.
Chitosan/Sodium Alginate/Velvet Antler Blood Peptides Hydrogel Promoted Wound Healing by Regulating PI3K/AKT/mTOR and SIRT1/NF-κB Pathways - Frontiersin.org
Article by Mingqian Hao, Xiaojuan Peng, Shuwen Sun, Chuanbo Ding and Wencong Liu (China - Front. Pharmacol.).
The authors' results showed that CAVBPH possessed desirable characteristics including thermo-sensitivity, antioxidation, antibacterial activity, biosafety, VBPs release behavior, etc., and significantly accelerated skin wound healing in mice.
The role of CTHRC1 in promotion of cutaneous wound healing - Nature.com
Article by Xianlan Duan, Xingyu Yuan, Bin Yao, Wei Song, Zhao Li, Enhejirigala, Yi Kong, Yuzhen Wang, Xiaobing Fu and Sha Huang (China - Signal Transduction and Targeted Therapy).
The authors revealed the dynamic expression of CTHRC1 during full-thickness skin wound healing.
How quickly does a wound heal? Bayesian calibration of a mathematical model of venous leg ulcer healing - Oup.com
Abstract by Adriana Zanca, James M Osborne, Sophie G Zaloumis, Carolina D Weller and Jennifer A Flegg (Mathematical Medicine and Biology).
What Is Standard of Care in Wound Care? - Woundsource.com
Patients with wounds are cared for according to the scope and standards of practice, which are used to guide nurses and other members of the interprofessional wound care team. An intricate network of physicians, medical researchers, government regulators, and medical journal contributors helps develop the standard of care.
Effectiveness of negative pressure wound therapy: Minimum five-year follow-up and review of the literature - Jointdrs.org
Article by Erzsébet Szabóné Révész, Áron Altorjay, Valéria Montskó and László Hangody (Székesfehérvár, Budapest, Hungary - JDRS).
This technique may be used as widely and as early as possible. However, further large-scale, multi-center, randomized clinical trials are needed worldwide to find a place for this technique in wound care and even in primary care.
Botulinum Toxin Type A for the Treatment of Skin Ulcers: A Review Article - Mdpi.com
Article by Waranaree Winayanuwattikun and Vasanop Vachiramon (Bangkok, Thailand - Toxins).
The results demonstrated some positive effects of BoNT-A on chronic ulcers.
Efficacy and safety of neuromuscular electrical stimulation in the prevention of pressure injuries in critically ill patients: a randomized controlled trial - PubMed
Abstract by Miriam Viviane Baron, Paulo Eugênio Silva, Janine Koepp, Janete de Souza Urbanetto, Andres Felipe Mantilla Santamaria, Michele Paula Dos Santos, Marcus Vinicius de Mello Pinto et al. (Brazil, Denmark - Ann Intensive Care).
Riclin-Capped Silver Nanoparticles as an Antibacterial and Anti-Inflammatory Wound Dressing - Dovepress.com
Article by Changchang Kong, Shijunyin Chen, Wenhao Ge, Yang Zhao, Xiaodong Xu, Shiming Wang and Jianfa Zhang (Nanjing, China - International Journal of Nanomedicine).
The reported Riclin-AgNPs nanocomposite hydrogel showed both antibacterial and anti-inflammatory functions, which induce significantly accelerated wound healing, indicating great potential as a novel attractive wound dressing material.
Electro-chemical bandages could be an effective alternative to antibiotics for managing wound infections - News-medical.net
Article by Emily Henderson.
According to new research by investigators at the Mayo Clinic and Washington State University, e-bandages could be an effective alternative to antibiotics for managing wound infections. The findings are presented at ASM Microbe 2022, the annual meeting of the American Society for Microbiology.
Potency assays for human adipose-derived stem cells as a medicinal product toward wound healing - PubMed
Abstract by Guoqiang Ren, Qiuyue Peng, Trine Fink, Vladimir Zachar and Simone Riis Porsborg (Aalborg, Denmark - Stem Cell Res Ther.).
Antimicrobial Activity and Wound-Healing Capacity of Birch, Beech and Larch Bark Extracts - Mdpi.com
Article by Stefanie Emrich, Anja Schuster, Thomas Schnabel and Gertie Janneke Oostingh (Austria, Romania - Molecules).
The aim of this work was to identify beneficial properties of Austrian larch, birch and beech bark extracts for their potential usage as additives or active ingredients in dermatological applications.
Drug loaded cellulose–chitosan aerogel microfibers for wound dressing applications - Springer.com
Article by M. Rostamitabar, A. Ghahramani, G. Seide, S. Jockenhoevel and S. Ghazanfari (The Netherlands, Germany - Cellulose).
The results showed that the CHCLAFs could be used as a promising candidate for wound dressing materials.
Chronic venous insufficiency: a comprehensive review of management - PubMed
Abstract by Julian Azar, Amit Rao and Alisha Oropallo (USA - J Wound Care).
Development of a user-friendly, hot-melt, wound-healing adhesive - Sciencedaily.com
Scientist have developed a hot-melt tissue adhesive (i.e., medical glue that is applied in a molten state) capable of healing operative wounds. This adhesive has excellent medical material properties in terms of its ease of use, adhesiveness to tissues, biocompatibility and ability to prevent postoperative complications.
Recent advances in metal-organic frameworks and their composites for the phototherapy of skin wounds - PubMed
Abstract by Mei Yang, Jin Zhang, Wu Shi, Jie Zhang and Chuanmin Tao (Chengdu, China - J Mater Chem B.).
Cytokines and Venous Leg Ulcer Healing – A Systematic Review - Mdpi.com
Article by Ewa A. Burian, Lubna Sabah, Tonny Karlsmark, Klaus Kirketerp-Møller, Christine J. Moffatt, Jacob P. Thyssen and Magnus S. Ågren (Denmark, UK - IJMS).
The authors conclude that non-healing VLUs may be associated with an elevation of a palette of pro-inflammatory cytokines, possibly reflecting activated innate immunity in these wounds.
Australian guideline on management of diabetes-related foot infection: part of the 2021 Australian evidence-based guidelines for diabetes-related foot disease - PubMed
Abstract by Robert J Commons, James Charles, Jane Cheney, Sarah A Lynar, Matthew Malone, Edward Raby and Australian Diabetes-related Foot Disease Guidelines & Pathways Project (Australia - J Foot Ankle Res.).
Novel Technologies in Chronic Wound Care - Thieme-connect.com
Abstract by Yehiel Hayun, Dafna Shilo Yaacobi, Tal Shachar, Moti Harats, Andrew E. Grush and Asaf Olshinka (Israel, USA - Semin Plast Surg.).
How Can Maggots Save Limbs? - News-medical.net
Article by Akanksha Singh. Maggot therapy has been used in the field of medicine since ancient times. It was popularized during the world wars due to frequent soldier injuries. Despite the patients’ reluctance in using this therapy, it has been gaining momentum largely due to recent advancements that have solved its shortcomings.
Interventions for the treatment and prevention of pressure ulcers - PubMed
Abstract by James Edward Hill, Sarah Edney, Oliver Hamer, Alexandra Williams and Catherine Harris (Lancashire, UK - Br J Community Nurs.).
Proteomics Identification of Targets for Intervention in Pressure Ulcers - PubMed
Abstract by Zhihong Peng, Trung T Nguyen, Man Wang, Bowen Anderson, Mohini Mohan Konai, Valerie A Schroeder, William R Wolter, Toni Page-Mayberry, Charles E Peterson, Shahriar Mobashery and Mayland Chang (USA - ACS Chem Biol.).
Successful Repigmentation of Full-Thickness Wound Healing in Fraser’s Dolphins (Lagenodelphis hosei) - Mdpi.com
Article by Chen-Yi Su, Hao-Ven Wang, Michael W. Hughes, Tzu-Yu Liu, Cheng-Ming Chuong and Wei-Cheng Yang (Taiwan, USA - Animals).
The auhors' results showed that the melanocyte density in Fraser’s dolphins was more related to the skin pigmentation than anatomical location and UV exposure, and the timing of melanocyte migration during wound healing in Fraser’s dolphins was different from humans.
Personalized Offloading Treatments for Healing Plantar Diabetic Foot Ulcers - PubMed
Abstract by Gustav Jarl, David F Rusaw, Alexander J Terrill, Cleveland T Barnett, Maria A Woodruff and Peter A Lazzarini (Sweden, Australia, UK - J Diabetes Sci Technol.).
Ending surgical site infection by negative pressure wound therapy (NPWT): A case report - PubMed
Abstract by Mansour Arad, Rasoul Goli, Mazhar Ebrahimzade, Mohammad Lorzini, Mahnaz Abdali and Nazila Sepehrnia (Iran - Int J Surg Case Rep.).
Closed Incision Negative Pressure Therapy vs Standard of Care Dressing in Breast Surgery: A Systematic Review - PubMed
Abstract by Amos Nepacina Liew, Kylie Yen-Yi Lim and Jeremy Fuquan Khoo (Australia - Cureus).
Hyperbaric oxygen therapy as an adjunct to the standard wound care for the treatment of diabetic foot ulcers in Indian patients: a cost utility analysis - PubMed
Abstract by Friji Meethale Thiruvoth, Subramania Raju Rajasulochana, Mathan Kumar S, Saravanan E, Parthibane Sivanantham and Sitanshu Sekhar Kar (Puducherry, India - Expert Rev Pharmacoecon Outcomes Res.).
Synthesis of Chitosan-Based Gold Nanoparticles: Antimicrobial and Wound-Healing Activities - Mdpi.com
Article by Amr H. Hashem, Amr M. Shehabeldine, Omar M. Ali and Salem S. Salem (Egypt, Saudi Arabia - Polymers).
The in vitro wound-healing model revealed that the Chi/AuNP dressing provides a relatively rapid and efficacious wound-healing ability, making the obtained nanocomposite a promising candidate for the development of improved bandage materials.
Clinical Uses of NPWT with Irrigation of Normal Saline in Diabetic Foot Ulcer: Outcome Assessed by DEPA Score - PubMed
Abstract by Vikas Kumar Malviya, Sakshi Goyal, Vishal Bansal and Kritik Jaiswal (Bhopal, India - J Cutan Aesthet Surg.).
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