Gauze Dressings and Wounds: 9 Dos and Don’ts - Woundsource.com
The use of wet-to-dry dressings has been the standard treatment for many wounds for decades. However, this technique is frowned on because it has various disadvantages. In this process, a saline-moistened dressing is applied to the wound bed, left to dry, and removed, generally within four to six hours.
Wound Drainage: How Does It Guide the Plan of Care? - Woundsource.com
Article by Holly Hovan. We have all heard the saying: a dry cell is a dead cell… we know that a moist wound bed is most conducive to healing. If a wound is too dry, we add moisture… and if a wound is too wet, we try to absorb the drainage. There must be a balance of moist and dry to promote an optimal healing environment. Much like a dry cell is a dead cell, a wound that is too moist often has delayed wound healing.
Wound Management Strategy for Treatment of Localized Cutaneous Leishmaniasis Using the TIME Framework - Woundresearch.com
Article by Michela Iannone, Teresa Oranges, Valentina Dini, Marco Romanelli and Agata Janowska (Pisa, Italy).
In the present case, the TIME approach simplified the local management of ulcerated CL, thereby improving both the healing process and cosmetic outcome.
Pyoderma Gangrenosum After Hand Surgery: A Case Report - Woundresearch.com
Article by Turkhan Mehdiyev and Robert Zimmermann (Innsbruck, Austria).
This case emphasizes the importance of early recognition of PG to provide a timely diagnosis and avoid unnecessary surgeries, which can result in devastating consequences.
Recent progress in preparation and applications of chitosan/calcium phosphate composite materials - PubMed
Abstract by Ahmed Salama (Giza, Egypt - Int J Biol Macromol.).
Structural characteristics of polysaccharide microcapsules from Nostoc commune, and their applications in skin wound healing and pathological repair - PubMed
Abstract by Yonggang Wang, Chenliang Wang, Jing Dang, Hongyan Xue, Xinjian Wang, Yongming Jin, Mingjun Yang, Feifan Leng and Baigang Zhang (Lanzhou, China - Biomed Mater.).
New Perspective to Improve Care of Patients with Infected Diabetic Foot Ulcer: Early Economic Impact of the Use of Photodynamic Therapy with RLP068 (Based) System - Dovepress.com
Article by Valentina Lorenzoni, Agatina Chiavetta, Vincenzo Curci, Giuseppe Della Pepa, Carmelo Licciardello, Felicia Pantò, Alessia Scatena and Giuseppe Turchetti (Italy - ClinicoEconomics and Outcomes Research).
The early economic evaluation performed suggested that, if the claimed effectiveness of the technology demonstrated in case reports and in preliminary clinical studies can be confirmed in larger population studies, and allowing for shortening of the time needed to activate the healing process, the PDT-RLP068 system could offer the chance to improve care for DFI patients without compromising the sustainability of the system.
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Study of Wound Healing Dynamics by Single Pseudo-Particle Tracking in Phase Contrast Images Acquired in Time-Lapse - Mdpi.com
Article by Riccardo Scheda, Silvia Vitali, Enrico Giampieri, Gianni Pagnini and Isabella Zironi (Spain, Italy - Entropy).
By studying the SPT statistics, the authors are able to identify an intermediate regime characterized by a constant average of the cellular front velocity and by exponential tails for the velocity increments’ distribution.
Incidental Finding of Tuberculosis During Evaluation for Delayed Wound Healing - Academic.oup.com
Article by Sabrina E Kunciw and Eric C de la Cruz (USA - Military Medicine).
This case serves to illustrate the long history of challenges the military medical community has faced with tuberculosis and to remind providers to be cognizant about local common diseases when serving overseas and include these diagnoses in their differentials.
Topical Oxygen Jet Therapy (TOJT) for treating infected chronic surgical wounds - PubMed
Abstract by Maria Helena Otaviano, Mauro Salles, Ting Hui Ching, Josilene Lopes Dettoni, Ieda Guedes Simões Coulibaly, Erika Tiemi Fukunaga, Mônica Antar Gamba and José Cássio de Moraes (São Paulo, SP, Brazil - Braz J Infect Dis.).
Patient and lay carer education for preventing pressure ulceration in at-risk populations - PubMed
Abstract by Tom O'Connor, Zena Eh Moore and Declan Patton (Dublin, Ireland - Cochrane Database Syst Rev.).
Wound healing in mucous tissues may prevent AIDS, claims study - Hindustantimes.com
Aspects of this wound-healing immune response could become targets for developing new therapies to prevent AIDS in people with HIV infections, according to the researchers from the University of Washington School of Medicine in the US.
Allogeneic Platelet-Rich Plasma: Is It Safe and Effective for Wound Repair? - PubMed
Abstract by Shiva Akbarzadeh, Maxwell B McKenzie, Md Mostafizur Rahman and Heather Cleland (Melbourne, Australia - Eur Surg Res.).
Scar free healing of full thickness diabetic wounds: A unique combination of silver nanoparticles as antimicrobial agent, calcium alginate nanoparticles as hemostatic agent, fresh blood as nutrient/growth factor supplier and chitosan as base matrix - PubMed
Abstract by Meenakshi Choudhary, Priyanka Chhabra, Amit Tyagi and Harpal Singh (India - Int J Biol Macromol.).
Pyoderma gangrenosum following an unplanned caesarean section: a patient revisited - PubMed
Abstract by Waseem Ghumra, Adam Gold and Richard Michael Azurdia (Liverpool, UK - BMJ Case Rep.).
Reconstruction of full thickness wounds using glyaderm in a single-staged procedure - PubMed
Abstract by Melissa de Henau, Anne Sophie Kruit and Dietmar J O Ulrich (The Netherlands - Cell Tissue Bank).
HvRNASET2 Regulate Connective Tissue and Collagen I Remodeling During Wound Healing Process - Frontiersin.org
Article by Nicolò Baranzini, Laura Pulze, Gianluca Tettamanti, Francesco Acquati and Annalisa Grimaldi (Varese, Italy - Frontiers in Physiology).
The results presented here not only confirms the authors' previous evidence, reporting that HvRNASET2 leads to an increased collagen production, but also shows that an overexpression of this protein might influence the correct progress of muscle tissue regeneration.
pdf (480 kB)!
Versatile Use of Chitosan and Hyaluronan in Medicine - Mdpi.com
Article by Katarína Valachová and Ladislav Šoltés (Bratislava, Slovakia - Molecules).
This review summarizes the main areas where these two biopolymers have an impact. The reviewed areas mostly cover most medical applications, along with non‐medical applications, such as cosmetics.
Chronic wounds stemming from heart disease can put patients at risk of amputation - Swoknews.com
Article by Jennifer James. Each year nearly 700,000 Americans are diagnosed with heart disease, which causes about 1 in 4 U.S. deaths, according to the Centers for Disease Control (CDC). Related complications like vascular insufficiency or peripheral artery disease can result in the development of non-healing wounds putting patients at risk of infection, sepsis, or lower limb amputation.
Combination of metronidazole and pearl powders for the treatment of stage 2 pressure injury wounds: Case report and literature review - PubMed
Abstract by Jinglin Guo, Fang Ji, Xue Zhang, Jing Han and Ju Zhang (Qingdao, China - Complement Ther Clin Pract.).
Diabetic foot: Which one comes first, the ulcer or the contracture? - PubMed
Abstract by Raden Andri Primadhi and Herry Herman (Bandung, Indonesia - World J Orthop.).
The Wound Healing Peptide, AES16-2M, Ameliorates Atopic Dermatitis In Vivo - Mdpi.com
Article by Myun Soo Kim, Jisun Song, Sunyoung Park, Tae Sung Kim, Hyun Jeong Park and Daeho Cho (Seoul, Korea - Molecules).
The expression of thymic stromal lymphopoietin was significantly reduced in AES16-2M-treated human keratinocytes. Therefore, these results suggest that AES16-2M can be a novel candidate for atopic dermatitis treatment.
Advanced Biofabrication Strategies for Skin Regeneration and Repair - Medscape.com
Article by Rúben F Pereira, Cristina C Barrias, Pedro L Granja and Paulo J Bartolo (Nanomedicine).
Skin is the largest organ of the body, serving primarily as a protective barrier against the environment. It also helps to prevent body dehydration and constitutes a physical barrier, limiting the penetration of potentially harmful agents to internal organs.
Pterostilbene accelerates wound healing by modulating diabetes-induced estrogen receptor β suppression in hematopoietic stem cells - Academic.oup.com
Article by Weiguo Xie, Xueqing Zhou, Weigang Hu, Zhigang Chu, Qiongfang Ruan, Haimou Zhang, Min Li, Hongyu Zhang, Xiaodong Huang and Paul Yao (Burns & Trauma).
Hematopoietic stem cells (HSCs) may play an important role in wound healing through transferring epigenetic modifications to subsequent PBMCs and macrophages by differentiation, while PTE accelerates diabetic wound healing by modulating diabetes-induced epigenetic changes in HSCs. Thus, PTE may be a novel therapeutic strategy for diabetic wound healing.
Nanoencapsulation of Chromolaena odorata Extract Using Pluronic F127 as an Effectively Herbal Delivery System for Wound Healing - Hindawi.com
Article by Ngoc-Dung Huynh Luu, Le Hang Dang, Hoang Minh Bui, Trang Thuy Thi Nguyen, Bich Tram Nguyen, Le Son Hoang and Ngoc Quyen Tran (Ho Chi Minh City, Vietnam).
The obtained results provided a promising prospect for raising the activity Chromolaena odorata extract in wound healing application.
A surfactant polymer wound dressing protects human keratinocytes from inducible necroptosis - Nature.com
Article by Puneet Khandelwal, Amitava Das, Chandan K. Sen, Sangly P. Srinivas, Sashwati Roy and Savita Khanna (USA).
The authors' findings show that TX100-induced plasma membrane damage and death by necroptosis were both attenuated by SPD, allowing keratinocyte survival. The significance of such protective effects of SPD on keratinocytes in wound re-epithelialization and closure warrant further studies.
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Neuropeptide Substance P Enhances Skin Wound Healing In Vitro and In Vivo under Hypoxia - Mdpi.com
Article by Suneel Kumar, Yuying Tan and Francois Berthiaume (New Jersey, USA - Biomedicine).
The data suggest that the Neuropeptide Substance P's has a beneficial role in wound closure and reepithelization, and thus enhanced wound healing, in male and female mice. Taken together, exogenously applied neuropeptide SP enhanced wound healing via cell proliferation and migration in vitro and in vivo.
How influential is the stiffness of the foam dressing on soft tissue loads in negative pressure wound therapy? - PubMed
Abstract by Aleksei Orlov and Amit Gefen (Tel Aviv, Israel - Med Eng Phys.).
Single-use negative-pressure wound therapy versus conventional dressings for closed surgical incisions: systematic literature review and meta-analysis - PubMed
Abstract by C Saunders, L M Nherera, A Horner and P Trueman (Hull, UK - BJS Open).
The effectiveness of a new dried human amnion derived membrane in addition to standard care in treating diabetic foot ulcers: A patient and assessor blind, randomised controlled pilot study - PubMed
Abstract by Fran Game, Katie Gray, Daniel Davis, Rachelle Sherman, Kamal Chokkalingam, Zak Connan, Apostolos Fakis and Michael Jones (UK - Int Wound J.).
Negative pressure wound therapy does not diminish efficacy of topical antibiotic powder in a preclinical contaminated wound model - PubMed
Abstract by Stefanie M Shiels, Nicole M Sgromolo and Joseph C Wenke (San Antonio, USA - Bone Joint Res.).
Three-dimensional shape-conformation performances of wound dressings tested in a robotic sacral pressure ulcer phantom - PubMed
Abstract by Adi Lustig and Amit Gefen (Tel Aviv, Israel - Int Wound J.).
Assessing Wound Tissue and Drainage Types: Slough Versus Purulence - Woundsource.com
Article by Holly Hovan. Wound assessment is one of the initial steps in determining the plan of care, changes in treatment, and the choice of key players in wound management. However, wound assessment needs to be accurately understood and documented by frontline staff to paint a true picture of what is happening with the wound.
A prospective, randomized, controlled, crossover study comparing three multilayered foam dressings for the management of chronic wounds - Futuremedicine.com
Article by Oscar M Alvarez, Mark S Granick, Alexander Reyzelman and Thomas Serena.
MxBF was more effective than AL or OGEX, in relation to the primary end point, dressing durability (wear time). MxBF was also rated more positively by investigators than the other dressings in relation to dressing characteristics, such as comfort, conformability, ease of handling, ability to stay intact, ease of application, ability to be repositioned, ability to stay in place and ease of removal.
Pressure Injury Prevention in Patients with Prolonged ED Stays Prior to Admission - PubMed
Abstract by Amanda Edwards, Novi Sitanggang, Kelly Wolff, Jewel Role, Trisha Cardona, Myra Sanchez and Patricia Radovich (USA - Am J Nurs.)
Jatropha Neopauciflora Pax Latex Exhibits Wound-Healing Effect in Normal and Diabetic Mice - PubMed
Abstract by Ana Bertha Hernandez-Hernandez, Francisco Javier Alarcon-Aguilar, Mario Garcia-Lorenzana, Marco Aurelio Rodriguez-Monroy and Maria Margarita Canales-Martinez (Mexico - J Evid Based Integr Med.).
Engineering multifunctional bactericidal nanofibers for abdominal hernia repair - Nature.com
Article by Samson Afewerki, Nicole Bassous, Samarah Vargas Harb, Marcus Alexandre F. Corat, Sushila Maharjan, Guillermo U. Ruiz-Esparza, Mirian M. M. de Paula, Thomas J. Webster, Carla Roberta Tim, Bartolomeu Cruz Viana, Danquan Wang, Xichi Wang, Fernanda Roberta Marciano and Anderson Oliveira Lobo (USA, Brazil - Communications Biology).
The nanofibers displayed good bactericidal activity, low inflammatory response, good biodegradation, as well as optimal collagen-, stress fiber- and blood vessel formation and associated tissue ingrowth in vivo. The disclosed engineering strategy serves as a prominent platform for the design of other multifunctional materials for various biomedical challenges.
Ex vivo conditioning of peripheral blood mononuclear cells of diabetic patients promotes vasculogenic wound healing - Wiley.com
Article by Rica Tanaka, Rie Ito‐Hirano, Satoshi Fujimura, Kayo Arita, Hiroko Hagiwara, Tomoya Mita, Masayoshi Itoh, Hideya Kawaji, Takasuke Ogawa, Hirotaka Watada, Haruchika Masuda, Takayuki Asahara and Hiroshi Mizuno (Japan, Stem Cells Translational Medicine).
This study demonstrates the therapeutic potential of a novel serum‐free QQc culture system using MNCs derived from patients with diabetes. Vasculogenic, anti‐inflammatory, and wound‐healing effects were demonstrated in both in vitro and in vivo models.
International Consensus Panel Recommendations for the Optimization of Traditional and Single-Use Negative Pressure Wound Therapy in the Treatment of Acute and Chronic Wounds - PubMed
Abstract by Theresa Hurd, Robert S Kirsner, Joan J Sancho-Insenser, Sian Fumarola, Alison Garten, Munir Patel, Leta McCarty Messinger and Rafael J Diaz-Garcia (USA, Spain, UK - Wounds).
Clinical Observations in Patients With Open Abdomens Managed With Negative Pressure Therapy Using a Perforated Foam Dressing: A Limited Case Series With Brief Literature Review - PubMed
Abstract by Luis G Fernández and Marc R Matthews (USA - Wounds).
Use of platelet concentrate gel in second-intention wound healing: a case report - Biomedcentral.com
Article by Vincenzo Davide Palumbo, Stefano Rizzuto, Giuseppe Damiano, Salvatore Fazzotta, Andrea Gottardo, Giuseppina Mazzola and Attilio Ignazio Lo Monte (Palermo, Italy - Journal of Medical Case Reports).
Topical application of homologous platelet-rich plasma gel in healing wound shows beneficial results in wound size reduction and induces granulation tissue formation. Platelet-rich plasma could be a safe and cost-effective treatment for managing the cutaneous wound healing process to shorten the recovery period and thereby improve patient quality of life.
Cerium oxide nanoparticle-loaded polyvinyl alcohol nanogels delivery for wound healing care systems on surgery - Tandfonline.com
Article by Lianlian Cao, Guojing Shao, Fengmei Ren, Minghua Yang, Yan Nie, Qian Peng and Peng Zhang (Dongying, China - Drug Delivery).
The authors findings indicate that Ce-nGel-Glu-based bandaging materials could be a potential candidate for wound healing applications in the future.
The CLI Global Society announces the Journal of Critical Limb Ischemia - Iwoundsnews.com
The CLI Global Society is launching the first peer-reviewed academic journal focusing on interventional techniques pertaining to critical limb ischemia (CLI). The new journal, Journal of Critical Limb Ischemia, is launching in the spring of 2021.
International consensus on pressure injury preventative interventions by risk level for critically ill patients: A modified Delphi study - PubMed
Abstract by Josephine Lovegrove, Paul Fulbrook and Sandra Miles (Australia, South Africa - Int Wound J.).
Nursing interventions for pressure injury prevention among critically ill patients: A systematic review - PubMed
Abstract by Bassam Alshahrani, Jenny Sim and Rebekkah Middleton (Australia, Saudi Arabia - J Clin Nurse).
Hydrogel promotes wound healing better than traditional bandages, gauzes - Sciencedaily.com
For explosion wounds as well as some incurred in disasters and accidents, severe hemorrhage is a leading cause of death. Hydrogel dressings, which have advanced in recent years, may help; they are good at promoting wound healing and can better meet the demands of different situations. Many are antibacterial, biodegradable, responsive, and injectable and can fill irregularly shaped wounds.
Recent advances on polymeric hydrogels as wound dressings featured - Scitation.org
Article by Zheng Pan, Huijun Yea and Decheng Wua (Shenzhen, China - APL Bioengineering).
In this Review, after introducing some commonly used strategies for the synthesis of hydrogels, the most recent progress on polymer-based hydrogels as wound dressings is discussed. Particularly, their hemostasis, antibacterial, and biodegradation properties are introduced. Finally, challenges and future perspectives about the development of hydrogels for wound dressings are outlined.
Effectiveness and safety of different dressings therapy for pressure injuries: A protocol for systematic reviews and network meta-analysis - PubMed
Abstract by Yitong Cai, Yuying Zhou, Lina Xing, Yingying Kang, Hailing Li, Peng Cheng and Yujuan Wang (China - Medicine (Baltimore)).
Effectiveness of using hydrocolloid dressing combined with 3M Cavilon No-Sting Barrier Film to prevent facial pressure injury on medical staff in a COVID-19 designated hospital in China: a self-controlled study - PubMed
Abstract by Shuanghong Zhang, Shidong Hu, Hezhen Chen and Xiaohui Jia (Wenzhou, China - Ann Palliat Med.).
Dermal Drivers of Injury-Induced Inflammation: Contribution of Adipocytes and Fibroblasts - Mdpi.com
Article by Paula O. Cooper, MaryEllen R. Haas, Satish kumar R. Noonepalle and Brett A. Shook (Washington, USA - IJMS).
In this review, the authors concentrate on the active participation of tissue-resident adipocytes and fibroblasts in pro-inflammatory signaling after injury, and how altered cellular communication from these cells can contribute to irregular inflammation associated with aberrant wound healing.
Which determinants are considered to be important for adherence to Negative Pressure Wound Therapy: A multimethods study - PubMed
Abstract by Alexandra H J Janssen, Johannes A Wegdam, Tammo S de Vries Reilingh, Hester Vermeulen and Anne M Eskes (The Netherlands, Australia - J Tissue Viability).
Garlic burn injuries- a systematic review of reported cases - PubMed
Abstract by Maja Hitl, Nebojša Kladar, Neda Gavarić, Branislava Srđenović Čonić and Biljana Božin (Novi Sad, Serbia - Am J Emerg Med.).
Sensors for a 'smart' wound bandage may track healing, immune response - Medicalxpress.com
Researchers from Skoltech and the University of Texas at Austin have presented a proof of concept for a wearable sensor that can track healing in sores, ulcers and other kinds of chronic skin wounds, even without the need to remove the bandages. The paper was published in the journal ACS Sensors.
A Systematic Review and Meta-Analysis of Wound Complications after a Caesarean Section in Obese Women - PubMed
Abstract by Aneta Słabuszewska-Jóźwiak, Jacek Krzysztof Szymański, Łukasz Jóźwiak and Beata Sarecka-Hujar (Poland - J Clin Med.).
"Doctor, how long will it take?" Results from an historical cohort on surgical pressure ulcer healing delay and related factors in persons with spinal cord injury - PubMed
Abstract by Anthony Gelis, Juliette Morel, Bouali Amara, Cécile Mauri, Hélène Rouays, Christine Verollet, Isabelle Almeras, Nicolas Frasson, Arnaud Dupeyron, Isabelle Laffont, Jean-Pierre Daures and Christian Herlin (France - J Tissue Viability).
Nurses' Knowledge and Attitudes towards Prevention of Pressure Ulcers - PubMed
Abstract by Beáta Grešš Halász, Anna Bérešová, Ľubomíra Tkáčová, Dagmar Magurová and Ľubomíra Lizáková (Slovakia - Int J Environ Res Public Health).
Extracellular matrix biomimetic polymeric membranes enriched with silver nanoparticles for wound healing - PubMed
Abstract by Laura Mihaela Stefan, Andreea Iosageanu, Daniela Ilie, Ana-Maria Stanciuc, Cristian Matei, Daniela Berger and Oana Craciunescu (Bucharest, Romania - Biomed Mater.).
Identification of the Potential Biomarkers Involved in the Human Oral Mucosal Wound Healing: A Bioinformatic Study - Hindawi.com
Article by Wanchen Ning, Xiao Jiang, Zhengyang Sun, Anthony Chukwunonso Ogbuehi, Wenli Gu, Aneesha Acharya, Zhaobi Fang, Xiongjie Zhu, Qianhua Ou, Muhui Zeng, Cong Li, Shiting Hua, Prabhakar Mujagond, Xiangqiong Liu, Yupei Deng, Hongying Pan, Shaonan Hu, Xianda Hu and Simin Li (Germany, China - BioMed Research International).
Genetic and epigenetic mechanisms and specific drugs were identified as significant molecular mechanisms and entities relevant to oral mucosal healing. These may be valuable potential targets for experimental research.
Nanotechnology Development for Formulating Essential Oils in Wound Dressing Materials to Promote the Wound-Healing Process: A Review - Mdpi.com
Article by Ilenia De Luca, Parisa Pedram, Arash Moeini, Pierfrancesco Cerruti, Gianfranco Peluso, Anna Di Salle and Natalie Germann (Italy, Germany - Applied Sciences).
This review summarizes recent studies concerning essential oils as active secondary compounds in polysaccharide-based wound dressings.
Cathelicidin ΔPb-CATH4 derived from Python bivittatus accelerates the healing of Staphylococcus aureus-infected wounds in mice - PubMed
Abstract by Soundrarajan Nagasundarapandian, Hye-Sun Cho, Somasundaram Prathap, Mingue Kang, Munjeong Choi, Yunjung Lee, Hyoim Jeon, Hyuk Song, Jin-Hoi Kim and Chankyu Park (Seoul, South Korea - Amino Acids).
A multifaceted intervention for evidence-based pressure ulcer prevention: a 3 year follow-up - PubMed
Abstract by Eva Sving, Lennart Fredriksson, Anna-Greta Mamhidir, Marieann Högman and Lena Gunningberg (Uppsala, Sweden - JBI Evid Implement.)
Effects of enteral nutrition on patients with pressure lesions: a single center, pilot study - PubMed
Abstract by G Stracci, E Scarpellini, E Rinninella, E V Mignini, N Clementi, M V Boni, M V Valeri, D Sansoni, L Abenavoli, A Gasbarrini, C Rasetti and P Santori (San Benedetto del Tronto, Italy - Eur Rev Med Pharmacol Sci.).
Compression Therapy: Indications, Types, and Application - Woundsource.com
Compression therapy is a well-established treatment modality for a number of conditions, including venous disorders, thrombosis, lymphedema, and lipedema. It is also very effective in treating various kinds of edema. Based on patient diagnostic data, many patients with these conditions can benefit from targeted compression therapy.
Getting to Know Granulation Tissue and What it Means for Wound Care - Woundsource.com
Article by Becky Naughton. Granulation tissue is a sign that the wound is on its way past an often-stubborn inflammatory phase of healing and progressing into the building phase of proliferation. But what exactly is granulation tissue?
Healing potential of Spirulina platensis for skin wounds by modulating bFGF, VEGF, TGF-ß1 and α-SMA genes expression targeting angiogenesis and scar tissue formation in the rat model - PubMed
Abstract by Zizy I Elbialy, Doaa H Assar, Aml Abdelnaby, Samah Abu Asa, Ehab Y Abdelhiee, Samar S Ibrahim, Mohamed M Abdel-Daim, Rafa Almeer and Ayman Atiba (Egypt, Saudi Arabia - Biomed Pharmacother.).
Efficacy of autologous platelet-rich plasma gel in the treatment of refractory pressure injuries and its effect on wound healing time and patient quality of life - PubMed
Abstract by Qian Liu, Ning Zhang, Zhengnan Li and Hongmei He (Ganzhou, China - Clinics (Sao Paulo)).
International comparison of pressure ulcer measures in long-term care facilities: Assessing the methodological robustness of 4 approaches to point prevalence measurement - PubMed
Abstract by Mircha Poldrugovac, Michael Padget, Lisette Schoonhoven, Nicola D Thompson, Niek S Klazinga and Dionne S Kringos (The Netherlands, France, United Kingdom, USA - J Tissue Viability).
An observational study protocol to explore loneliness and systemic inflammation in an older adult population with chronic venous leg ulcers - Biomedcentral.com
Article by Teresa J. Kelechi, Robin C. Muise-Helmericks, Laurie A. Theeke, Steven W. Cole, Mohan Madisetti, Martina Mueller and Margaret A. Prentice (USA - BMC Geriatrics).
Findings are expected to improve understanding of molecular mechanisms common to loneliness and inflammation towards development of a biopsychosocial prognostic indicator of healing potential in persons with chronic wounds.
Isoegomaketone from Perilla frutescens (L.) Britt Stimulates MAPK/ERK Pathway in Human Keratinocyte to Promote Skin Wound Healing - Hindawi.com
Article by Ye-Ram Kim, Bomi Nam, Ah-Reum Han, Jin-Baek Kim and Chang Hyun Jin(Jeongeup, USA - Evidence-Based Complementary and Alternative Medicine).
This study demonstrates isoegomaketone as a potential candidate to upregulate wound healing that may provide therapeutic benefits to patients with delayed wound healing.
Negative Pressure Wound Therapy With Instillation and Dwell Time for the Management of Complex Wounds: A Case Series - PubMed
Abstract by Samantha Delapena, Luis G Fernández, Kevin N Foster and Marc R Matthews (USA - Wounds).
Negative Pressure Wound Therapy With Instillation and Dwell Time Used to Treat a Deep Foot Abscess With a Small Plantar Surface Incision - PubMed
Abstract by Aprine Tan, Jackie Tey, Kimberley Leow and Keng Lin Wong (Singapore - Wounds).
Negative Pressure Wound Therapy With Instillation and Dwell Time Modifications for Lower Limb Wounds With the Waterfall Technique: A Case Series - PubMed
Abstract by Kimberley Leow, Jackie Tey, Aprine Tan, Kimberly Tan and Keng Lin Wong (Singapore - Wounds).
Negative Pressure Wound Therapy With Instillation and Dwell Time Used to Treat a Complex Open (Terrible Triad) Injury of the Elbow: A Case Report - PubMed
Abstract by Mazen Ali, Fekhaoui Mohammed Reda, Mahdi Gargouri, Hichem Issaoui, Hatem Abbassi and Fredson Razanabola (France, Morocco - Wounds).
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Diagnosing Burn Wounds Infection: The Practice Gap & Advances with MolecuLight Bacterial Imaging - Mdpi.com
Article by Nawras Farhan and Steven Jeffery (Birmingham, UK - Diagnostics).
The authors highlight the benefits that could be obtained through the use of this technology as well as the limitations and the feasibility of incorporating this novel procedure into the standard of care.
Hemostatic and antibacterial PVA/Kaolin composite sponges loaded with penicillin–streptomycin for wound dressing applications - Nature.com
Article by Tamer M. Tamer, Maysa M. Sabet, Ahmed M. Omer, Eman Abbas, Alaa I. Eid, Mohamed S. Mohy-Eldin and Mohamed A. Hassan (Egypt).
PVA-K0.1 sponge could be applied as a multifunctional wound dressing.
Negative-pressure Wound Therapy for Sacral Pressure Ulcer in Gorham-Stout Disease - PubMed
Abstract by Ichiro Shiokawa, Naoya Oshima, Nao Mizumura and Akira Momosawa (Yamanashi, Japan - Plast Reconstr Surg Glob Open).
Clinical effectiveness of omental transposition in facilitating perineal wound healing after abdominoperineal resection: a systematic review - PubMed
Abstract by Sungjin Kim, Sung Il Kang, Sohyun Kim and Jae Hwang Kim (Daegu, South Korea - Yeungnam Univ J Med.).
Pinocembrin and its linolenoyl ester derivative induce wound healing activity in HaCaT cell line potentially involving a GPR120/FFA4 mediated pathway - PubMed
Abstract by Sarah Mazzotta, Paolo Governa, Vittoria Borgonetti, Paola Marcolongo, Claudio Nanni, Alessandra Gamberucci, Fabrizio Manetti, Federica Pessina, Gabriele Carullo, Antonella Brizzi and Francesca Aiello (Italy - Bioorg Chem.).
The Role of Oxidative Stress and Antioxidants in Diabetic Wound Healing - Hindawi.com
Article by Liling Deng, Chenzhen Du, Peiyang Song, Tianyi Chen, Shunli Rui, David G. Armstrong and Wuquan Deng (Chongqing, China - Oxidative Medicine and Cellular Longevity).
The authors provide an update on the role of oxidative stress and antioxidants in diabetic wound healing through following four perspectives. They then discuss several therapeutic strategies especially dietary bioactive compounds by targeting oxidative stress to improve wounds healing.
Cytotoxicity and Epidermal Barrier Function Evaluation of Common Antiseptics for Clinical Use in an Artificial Autologous Skin Model - Mdpi.com
Article by María I. Quiñones-Vico, Ana Fernández-González, Elena Pérez-Castejón, Trinidad Montero-Vílchez and Salvador Arias-Santiago (Granada, Spain - JCM).
The authors' results may be useful for treatment protocols after implantation of BASS in patients and evaluating them in clinical practice. BASS represent a suitable model to test in vitro the impact of different treatments of other skin wounds.
Clinical and phytochemical studies of Plantago major in pressure ulcer treatment: A randomized controlled trial - PubMed
Abstract by Masoud Ghiasian, Zahra Niroomandi, Dara Dastan, Jalal Poorolajal, Fateme Zare and Sara Ataei (Hamadan, Iran - Complement Ther Clin Pract.).
A Multicenter, Prospective Randomized Trial of Negative Pressure Wound Therapy for Infrainguinal Revascularization with a Groin Incision - PubMed
Abstract by Daniel J Bertges, Lisa Smith, Rebecca E Scully, Mark Wyers, Jens Eldrup-Jorgensen, Bjoern Suckow, C Keith Ozaki and Louis Nguyen (USA - J Vasc Surg.).
Negative pressure wound therapy for skin necrosis prevention after snakebite in the emergency department: A retrospective cohort study - PubMed
Abstract by Kwan Jae Kim, Jin Hong Min, Insool Yoo, Seung Whan Kim, Jinwoong Lee, Seung Ryu, Yeon Ho You, Jung Soo Park, Won Joon Jeong, Yong Chul Cho, Se Kwang Oh, Yong Nam In, Hong Joon Ahn, Chang Shin Kang, Hyunwoo Kyung, Byung Kook Lee, Dong Hun Lee and Dong Hoon Lee (South Korea - Medicine (Baltimore)).
Bioengineered Skin Substitutes: Advances and Future Trends - PubMed
Article by Shima Tavakoli and Agnes S. Klar (Iran, Switzerland - Applied Sciences).
The authors present recent advances in the field of bioengineered human skin substitutes using three-dimensional (3D) bioprinting techniques.
Topical application of HA-g-TEMPO accelerates the acute wound healing via reducing reactive oxygen species (ROS) and promoting angiogenesis - PubMed
Abstract by Junjun Li, Rong Du, Qiong Bian, Danping Zhang, Siqian Gao, Anran Yuan, Xiaoying Ying, Youqing Shen and Jianqing Gao (Hangzhou, China - Int J Pharm.).
A dehydrated, aseptically-processed human amnion/chorion allograft accelerates healing in a delayed murine excisional wound model - PubMed
Abstract by David Dolivo, Ping Xie, Chun Hou, Abigail Phipps, Thomas Mustoe, Seok Hong and Robert Galiano (China, USA - Exp Cell Res.).
Fabrication of ciprofloxacin-loaded chitosan/polyethylene oxide/silica nanofibers for wound dressing application: In vitro and in vivo evaluations - PubMed
Abstract by Samaneh Hashemikia, Farhad Farhangpazhouh, Maliheh Parsa, Maryam Hasan, Atiyeh Hassanzadeh and Mehrdad Hamidi (Iran - Int J Pharm.).
Review: Efficacy of MMP-Inhibiting Wound Dressings in the Treatment of Hard-to-Heal Wounds: A Systemic Review - Woundsource.com
Hard-to-heal wounds, such as diabetic foot ulcers, pressure injuries, and venous leg ulcers, comprise a significant portion of health care visits, and these wounds place a physical and economic burden on many patients. These hard-to-heal wounds are defined as wounds with stagnant or delayed stages of healing that fail to resolve within eight weeks.
The Amputation Crisis of African American Patients - Woundsource.com
Article by Alton R. Johnson Jr. According to a study published by Geiss et al. based on data collections from 2000 to 2015, there has been an increase in total, major, and minor amputations in young (age 18-44 years) and middle-aged (45-64 years) adults, with amputations in Black men being more prevalent than in women of all ethnicities.
New shock wave technology heals diabetics’ feet faster - Cleveland19.com
Diabetes patients who suffer from painful, chronic wounds are seeing incredible results, and quickly, from a new wound healing therapy offered by University Hospitals.
Treatment of Pediatric Sternotomy Wound Complications: A Minimally Invasive Approach - PubMed
Abstract by Taehee Jo, Joon Hur and Eun Key Kim (South Korea - Thorac Cardiovasc Surg.).
Camelina lipid droplets as skin delivery system promotes wound repair by enhancing the absorption of hFGF2 - PubMed
Abstract by Hongtao Gao, Fawei Wang, Xinngli Hu, Yulin Li, Yuan Zhang, Kue Foka Idrice Carther, Bin Wang, Fei Min, Xue Wang, Hao Wu, Keheng Xu, Yonggang Zhou, Xin Liu, Xiaokun Li and Haiyan Li (China - Int J Pharm.).
Accelerated Wound Closure of Deep Partial Thickness Burns with Acellular Fish Skin Graft - Mdpi.com
Article by Randolph Stone II, Emily C. Saathoff, David A. Larson, John T. Wall, Nathan A. Wienandt, Skuli Magnusson, Hilmar Kjartansson, Shanmugasundaram Natesan and Robert J. Christy (Sam Houston, USA - IJMS).
The authors show that FSG integrated faster without increased contraction, resulting in quicker wound closure without skin graft application which suggests FSG improved burn wound healing over FBD.
pdf (1,1 mB)!
Made in Germany: A Quality Indicator Not Only in the Automobile Industry But Also When It Comes to Skin Replacement:
How an Automobile Textile Research Institute Developed a New Skin Substitute - Mdpi.com
Article by Herbert Leopold Haller, Matthias Rapp, Daniel Popp, Sebastian Philipp Nischwitz and Lars Peter Kamolz (Austria, Germany - Medicina).
Successful research and development cooperation between a textile research institute, the German Federal Ministry of Education and Research via the Center for Biomaterials and Organ Substitutes, the University of Tübingen, and the Burn Center of Marienhospital, Stuttgart, Germany, led to the development of a fully synthetic resorbable temporary epidermal skin substitute for the treatment of burns, burn-like syndromes, donor areas, and chronic wounds.
Formulation Development of Topical Preparation Containing Nanoparticles of Povidone-Iodine for Wound Healing - PubMed
Abstract by Dinesh Puri, Ankit Mishra, Alok Pratap Singh, Praveen Kumar Gaur, Monika Singh and Mod Yasir (India, Ethiopia - Assay Drug Dev Technol.).
Oral nutritional supplements effective therapeutic option for hard-to-heal wounds, study finds - Iwoundsnews.com
Specialised oral nutritional supplement can be a therapeutic option for hard-to-heal wounds, conclude Adriano A Mehl (Universidade Tecnológica Federal do Paraná, Curitiba, Brazil) and colleagues in the Journal of Wound Care.
Management of Acute Soft Tissue Injuries of the Cheek and Principles of Scar Revision - PubMed
Abstract by Caroline Hudson and Krista Olson (Houston, USA - Facial Plast Surg.).
Understanding Wound Documentation Goals for Your Care Setting - Woundsource.com
Up to 20% of all US medicolegal claims and more than 10% of settlements are wound related. Documentation is essential for all health care settings; however, there are differences in each setting. Knowing your clinical setting’s requirements from a documentation standpoint is critical in meeting documentation needs.
Team develops portable device that creates 3D images of skin in 10 minutes - Sciencedaily.com
A team from Nanyang Technological University, Singapore (NTU Singapore) has developed a portable device that produces high-resolution 3D images of human skin within 10 minutes.
The team said the portable skin mapping (imaging) device could be used to assess the severity of skin conditions, such as eczema and psoriasis. As the device also maps out the depth of the ridges and grooves of the skin at up to 2mm, it could also help with monitoring wound healing.
Mealworm Oil (MWO) Enhances Wound Healing Potential through the Activation of Fibroblast and Endothelial Cells - Mdpi.com
Article by Joung-Hee Kim, Eun-Yeong Kim, Kyu Jin Chung, Jung-Hee Lee, Hee-Jung Choi,Tae-Wook Chung and Keuk-Jun Kim (South Korea - Molecules).
The authors' results demonstrate that MWO might have potential as a therapeutic agent for the treatment of skin wounds.
Combined application of geranylgeranylacetone and amelogenin promotes angiogenesis and wound healing in human periodontal ligament cells - PubMed
Abstract by Hiroaki Yamato, Terukazu Sanui, Karen Yotsumoto, Yuki Nakao, Yukari Watanabe, Chikako Hayashi, Ryosuke Aihara, Misaki Iwashita, Urara Tanaka, Takaharu Taketomi, Takao Fukuda and Fusanori Nishimura (Japan - J Cell Biochem.).
Perineal wound complication risk factors and effects on survival after abdominoperineal resection of rectal cancer: a single-centre retrospective study - PubMed
Abstract by Chao Wang, Junyu You, Zhanlong Shen, Kewei Jiang, Zhidong Gao and Yingjiang Ye (Beijing, China - Int J Colorectal Dis.).
From wound response to repair – lessons from C. elegans - Springeropen.com
Article by Yicong Ma, Jing Xie, Chandra Sugiarto Wijaya and Suhong Xu (Hangzhou, China).
The authors review recent findings in how C. elegans epidermis responds to wounding and initiates early actin-polymerization-based wound closure as well as later membrane repair. They also discussed some remained outstanding questions for future study.
Convergent Validity of Three Pressure Injury Risk Assessment Scales: Comparing the PPRA-Home (Pressure Injury Primary Risk Assessment Scale for Home Care) to Two Traditional Scales - Dovepress.com
Article by Masushi Kohta, Takehiko Ohura, Katsuyuki Okada, Yoshinori Nakamura, Eiko Kumagai, Hitomi Kataoka, Tomomi Kitagawa, Yuki Kameda and Toshihiro Kitte (Japan).
The AUC for the PPRA-Home as scored by care managers was similar to those of the Braden and OH scales as scored by physicians or expert nurses.
Bioimpedance method for monitoring venous ulcers: Clinical proof-of-concept study - PubMed
Abstract by Atte Kekonen, Mikael Bergelin, Jan-Erik Eriksson, Annikki Vaalasti, Heimo Ylänen, Sami Kielosto and Jari Viik (Finland - Biosens Bioelectron.).
Negative pressure wound therapy in grade 1 and 2 diabetic foot ulcers: A randomized controlled study - PubMed
Abstract by Haraesh Maranna, Pawan Lal, Anurag Mishra, Lovenish Bains, Gaurish Sawant, Rahul Bhatia, Pritesh Kumar and Mohd Yasir Beg (New Delhi, India - Diabetes Metab Syndr.).
Petite miracles: insight into the nano-management of scarless wound healing - PubMed
Abstract by Bei Ho Pan, Qiang Zhang, Chun Hei Lam, Ho Yin Yuen, Shifeng Kuang and Xin Zhao (China - Drug Discov Today).
£1.7m project to explore groundbreaking new treatment for biofilm infections in foot ulcers - Miragenews.com
A new £1.7m project to explore using plasma jets and antimicrobial dressings to treat debilitating – and potentially deadly – wound infections launches today. The groundbreaking Plasma-activated Antimicrobial Hydrogel Therapy (PAHT) would provide a new treatment modality for biofilm infections in diabetic foot ulcers (DFUs), a type of wound which make up around 10 per cent of the 2.2m wounds reported annually in the UK.
Human keratinocyte-derived extracellular vesicles activate the MAPKinase pathway and promote cell migration and proliferation in vitro - Biomedcentral.com
Article by Azela Glady, Arno Vandebroek and Masato Yasui (Tokyo, Japan - Inflammation and Regeneration).
HaCaT cell-derived EVs accelerate the migration and proliferation of human keratinocytes and fibroblasts and may promote wound healing via the activation of MAPKinase pathways. These findings may be key in developing new methods to treat wounds and accelerate wound healing in the future.
pdf (1,1 mB)!
The Therapeutic Effect and In Vivo Assessment of Palmitoyl-GDPH on the Wound Healing Process - Mdpi.com
Article by Nur Izzah Md Fadilah, Mohd Basyaruddin Abdul Rahman, Loqman Mohamad Yusof, Noordin Mohamed Mustapha and Haslina Ahmad (Selangor, Malaysia - Pharmaceutics).
The authors' indisputably supported the great potential of this newly synthesized Palmitoyl-GDPH to be used as an effective therapeutic agent for wound healing (this actually means creating a new wound).
Surgical Wound Infection Prevention using Topical Negative Pressure Therapy on Closed Abdominal Incisions - The "SWIPE IT" Randomised Clinical Trial - PubMed
Abstract by Angelina Marina Di Re, Danette Wright, James Wei Tatt Toh, Toufic El-Khoury, Nimalan Pathma-Nathan, Martijn Pieter Gosselink, Sukhwant Khanijaun, Sudarsanam Raman and Grahame Ctercteko (Australia, Aruba - J Hosp Infect.).
EWMA 2021: Submit your abstract - Ewma.org
The organisers invite you to share your latest research with the wound healing society at the EWMA 2021 Conference.
International abstract submission deadline is 10 February, 2021 (23.59 CET).
Hard-to-Heal Wounds: The Effects of Biofilm - Woundsource.com
Biofilms are found in the majority of chronic wounds and pose a critical health threat, causing nearly 80% of refractory nosocomial infections. They also have a damaging virulence mechanism, which induces resistance to antimicrobials and evasion from the host’s immune system.
Nanotized praseodymium oxide collagen 3-D pro-vasculogenic biomatrix for soft tissue engineering - PubMed
Abstract by Vinu Vijayan, Sreelekshmi Sreekumar, Fathe Singh, Kunnavakkam Vinjimur Srivatsan, Rachita Lakra, Korrapati Purna Sai and Manikantan Syamala Kiran (Chennai, India - Nanomedicine).
Green Tea Derivative Driven Smart Hydrogels with Desired Functions for Chronic Diabetic Wound Treatment - Wiley.com
Abstract by Xiaodan Zhao, Dandan Pei, Yuxuan Yang, Kai Xu, Jing Yu, Yuchen Zhang, Qiang Zhang, Gang He, Yanfeng Zhang, Ang Li, Yilong Cheng and Xuesi Chen (Advanced Functional Materials).
Exploration of Bioengineered Scaffolds Composed of Thermo-Responsive Polymers for Drug Delivery in Wound Healing - Mdpi.com
Article by Luis Castillo-Henríquez, Jose Castro-Alpízar, Mary Lopretti-Correa and José Vega-Baudrit (Costa Rica, Uruguay - IJMS).
This paper integrates the relevant reported contributions of bioengineered scaffolds composed of smart thermo-responsive polymers for drug delivery applications in wound healing.
Complications of Hyperbaric Oxygen Treatment - Hopkinsmedicine.org
During hyperbaric oxygen therapy (HBOT), you breathe pure oxygen inside a highly pressured environment. Often, pressure in the chamber is between 1.5 and 3 times greater than normal air pressure.
Proangiogenic Peptide Nanofiber Hydrogels for Wound Healing - PubMed
Abstract by Bin Chu, Jin-Mei He, Lan-Lan Liu, Chao-Xi Wu, Ling-Ling You, Xiao-Li Li, Song Wang, Chang-Sheng Chen and Mei Tu (China - ACS Biomater Sci Eng.).
Current Overview of Obesity-Induced Lymphedema - PubMed
Abstract by Christopher L Sudduth és Arin K Greene (Boston, USA - Adv Wound Care (New Rochelle)).
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