Hungarian Wound Care Society

In Vitro, In Vivo, and Clinical Trial Approaches to Investigate the Effects of Medicinal Plants on Burn Wound Healing: A Systematic Review - Wiley.com
Article by Mahdi Bagheri, Seyed Mohammad Zarei, Mostafa Soodmand, Hossein Mardani Nafchi and Mir Hossein Hashemi Poor (Iran - International Wound Journal). Various medicinal plants discussed in this review improve the burn wound healing process due to the presence of diverse biological compounds with antioxidant, anti-inflammatory and antibacterial properties. These plants affect the four phases of wound healing. These plant species and their compounds could be potentially used for the development of effective natural remedies against burn wounds.

Protein linked to cancer plays key role in wound healing - News-medical.net
When doctors detect elevated levels of SerpinB3 in a blood test, it can signal that something is seriously wrong, from hard-to-treat cancers to severe inflammatory conditions. SerpinB3 is a critical protein that often reveals when the body's barrier tissues, like the skin or lungs, are under serious stress from cancer or chronic illness.

Postoperative Wound Care Practices of Acute Care Nurses: An Integrative Review - Wiley.com
Article by Gayani Priyangika Gamage, Josephine Lovegrove, Sanjeewa Seneviratne, Georgia Tobiano and Brigid Gillespie (Australia, Sri Lanka - International Wound Journal). This integrative review highlights that acute care nurses predominantly focused on technical dressing procedures with limited emphasis on comprehensive assessment, documentation, nutrition and patient education. Therefore, adopting a more holistic approach in surgical wound care could minimize practice variations among nurses.

Silicone-based fluid gel versus white paraffin ointment in the treatment of post-fractional ablative CO2 laser wound: an intra-individual split-face comparative study - PubMed
Abstract by Abdulmajeed Alajlan, Sadan AlHarbi, Khalid Nabil Nagshabandi, Ahmed Alajlan et al. (Saudi Arabia - J Dermatolog Treat.).

Next-Generation Wound Care: Guiding the Body to Heal Itself - Asiaresearch.com
Researchers at National Taiwan University have discovered how light, electricity, and tiny forces can work together to help wounds heal naturally and leave fewer scars, offering new hope for chronic wound care.

Smart hydrogel mimics skin repair to accelerate diabetic wound healing - Eurekalert.com
Researchers develop a bioinspired composite hydrogel that integrates antibacterial, immunomodulatory, and regenerative functions for chronic wound care.

Development and Characterization of a Wound-Healing System Based on a Marine Biopolymer -Mdpi.com
Article by Catalina Natalia Cheaburu Yilmaz, Melisa Sirin Yildirim, Defne Govem, Hulya Ayar Kayali and Onur Yilmaz (Izmir, Turkey - Gels). The formulated hydrogels exhibited significant swelling capacity, antioxidant activity, and the selected optimal formulation exhibited enhanced wound closure rates in vitro, demonstrating potential for wound-healing applications.

In Vitro Analysis of the Dynamic Role of the Bacterial Virulence Factors in Skin Wound Healing - Mdpi.com
Article by Ayat S Hammad, Sarah H. Zahedy, Shatha S. Elqasass, Sawsan Sudqi Said et al. (Qatar, Jordan - IJMS). The authors' findings highlight that bacterial virulence factors have variable impacts on acute wound healing.

Effectiveness of Negative Pressure Wound Therapy and Advanced Interventions in Preventing Surgical Site Infections: A Systematic Review - Cureus.com
Article by Muaz Hassan, Mohamed Eltayeb Abdelrahman Naiem, Moustafa U. Abdelradi, Rasha Omer Babiker Mohamed et al. (UK, Sudan). The effectiveness of NPWT and advanced wound interventions in preventing SSIs is not universal but is contingent on the specific surgical context. These technologies should be applied selectively, targeting patient populations and procedures where a clear benefit has been demonstrated, rather than being used routinely.

Wound Healing: Harnessing Extracellular Vesicles Derived from Adipose-Derived Stem Cells - Dovepress.com
Article by Qisong Liu, Cuiping Zhang, Yujie Liang and Xiaohua Pan (China - International Journal of Nanomedicine). Chronic wounds present a significant clinical challenge, placing a heavy burden on patients and highlighting the need for more effective treatments. Among emerging strategies, adipose-derived stem cells and their extracellular vesicles show great promise due to their potent wound-healing capabilities.

Microwave therapy promotes wound healing in diabetic mice by activating IL-33/ST2-mediated M2 macrophage polarization - Nature.com
Article by Miaoxin He, Xinglan Huang, Tao Liu, Qian Yang et al. (China - Scientific Reports). The authors' findings provide mechanistic insight into the immunomodulatory effects of microwave therapy and support its potential as a non-invasive strategy for chronic diabetic wound management.

Standardised Algorithm for Peri- and Postoperative Wound Management Using Fish Skin Grafts and Octenidine in Head–Neck Surgery - Wiley.com
Article by Lukas S. Fiedler, Burkard M. Lippert, Christoph Klaus, Michaela Plath and Greta Zweigart (Germany - International Wound Journal). The authors' case series presents a novel treatment protocol including a modern antiseptic molecule for wound bed preparation. Octenidine seems to support granulation and reduces additionally needed interventions in non-irradiated patients.

Wound Healing Problems After Spinal Surgery: A Study on Possible Causes and Solutions - Wiley.com
Article by Derya Karaoğlu Gündoğdu, Yunus Kaçar and Emel Korkmaz (Ankara, Turkey - International Wound Journal). This article aims to introduce "Wound Healing Problem" as a new concept, setting a foundation for further studies.

Endothelial Effects in the Elderly: Fibroblast Regulation in Soft Tissue Healing - Nih.gov
Article by Martin Oberringer, Martina Jennewein, Monika Bubel, Silke Guthörl and Tim Pohlemann (Homburg, Germany - J Cell Physiol.). The authors' results deliver new insights into the age dependent process of tissue repair. Characteristics of pre‐senescent fibroblasts in terms of modified proliferation, cell morphology, cell cycle regulation, myofibroblastoid differentiation and cytokine release indicate a strong responsibility of this phenotype for the composition and function of a granulation tissue at different locations, including vascular sites. In its entirety, the results support the assumption, that a missing clearance of the senescence phenotype in late stages of tissue repair is one of the main reasons for healing failure.

A Case of Complete Epithelialization of an Extensive Foot Wound With Exposed Calcaneus Using Topical Cadexomer Iodine (CIOD) Monotherapy - Cureus.com
Article by George Miura, Norihiro Yoshimoto, Suguru Kurosawa, Yoichiro Oda et al. (Kushiro, Japan). Authors report a case of complete epithelialization of a large debrided wound achieved with topical CIOD. This case highlights the potential utility of cadexomer iodine monotherapy for limb preservation through its sustained antimicrobial activity, inhibition of biofilm formation, control of exudate, and facilitation of autolytic debridement in high-risk patients.

How clinical structures shape diagnostic practices in Swedish hard-to-heal ulcer care: a grounded theory study - Bmj.com
Article by Jenny Roxenius, Hanna Linnea Wickstrom, Lisa Skär and Frank Oien (Sweden - BMJ Open). This study can be used to get a deeper understanding of the challenges of current wound management, where clinical governance can support or undermine the movement from a traditional work distribution towards an evidence-based clinical practice.

Synergistic Wound Healing: Unraveling the Multi-Target Effects of Traditional Chinese Medicine and Its Biomaterials on Chronic Wound Pathways - Tandfonline.com
Article by Jiayu Shen, Zhuo Tong, Bing Han, Ziyin Zhang et al. (Changchun, China - International Journal of Nanomedicine). Innovative formulations, such as curcumin-loaded hydrogels and exosome-based systems, enhance antioxidant, anti-inflammatory, and pro-angiogenic activities, accelerating wound closure. Despite progress, challenges remain in optimizing multifunctional co-assembly systems, elucidating NPHM self-assembly mechanisms, and developing smart biomaterials responsive to dynamic wound microenvironments.

Antibacterial and Biocompatible Penicillin–Streptomycin Loaded Bacterial Cellulose (BC) Hydrogels for Wound Healing - Mdpi.com
Article by Sanosh Kunjalukkal Padmanabhan, Maria Elena Giordano, Stefania Villani, Gayatri Udayan et al. (Lecce, Italy - Gels). Antibacterial activity, assessed via agar diffusion against Pseudomonas aeruginosa and Staphylococcus aureus, showed a concentration-dependent increase in inhibition zones, highlighting the potential of BC-Pen/Strep hydrogels as effective antimicrobial wound dressings.

Herbal medicine in chronic wounds in Calabria region of Italy: an ethnographic study - Frontiersin.org
Article by Davide Costa and Raffaele Serra (Catanzaro, Italy - Front. Sociol.). The authors' findings reveal that older women, particularly grandmothers and mothers, are the primary custodians of local ethnomedical knowledge. Remedies such as Achillea millefolium poultices and Citrus bergamia decoctions are employed to treat various types of chronic wounds, including venous, arterial, and diabetic ulcers.

Advancing Chronic Wound Care With Near-Infrared Spectroscopy Imaging: Clinical Applications, Measurement Parameters, and Insights Into Healing Dynamics - Hmpgloballearningnetwork.com
Article by Alisha Oropallo, Alex G. Ortega-Loayza, Holly Korzendorfer, Francis James et al. (USA, Canada - Wounds). NIRS imaging advances wound management by providing real-time, noninvasive, and objective data on tissue oxygenation and perfusion. NIRS imaging may objectively complement the standard percentage area reduction assessments during the wound treatment process.

Reframing chronic wound therapy: from growth factor delivery to regenerative immuno-engineering - Frontiersin.org
Article by Zhiyong Wang, Xuan Zeng, Wenzhao Feng, Yanxin Lu and Pei Wei (China - Front. Immunol.). The long-standing failure to translate basic fibroblast growth factor nanodelivery systems into clinical reality is not an indictment of nanotechnology, but of a research paradigm that has been divorced from fundamental immunology.

Near-Infrared Spectroscopy Shows Promise in Equitable Early Detection of Deep Tissue Injuries - Woundsource.com
Article by Kirra Fedyszyn. In a poster presented at the Symposium on Advanced Wound Care Fall 2025, researchers examine the role near-infrared spectroscopy may play in helping to accurately diagnose deep tissue and pressure injuries in patients of diverse skin tones.

Advanced Wound Therapies - PubMed
Abstract by R. G. Frykberg and John H. Speight (USA - Clin Podiatr Med Surg.).

Approach to Partial Foot Amputations - PubMed
Abstract by Rahul Mishra, Nick Swerdlow and Mark C. Wyers (Boston, USA - Clin Podiatr Med Surg.).

Targeting bacterial communication may offer antibiotic-free wound therapy - News-medical.net
Researchers at University of California San Diego School of Medicine have discovered a previously unrecognized mechanism by which Staphylococcus aureus - one of the most common causes of skin and soft tissue infections worldwide - delays wound healing. The new study reveals that quorum sensing - a process in which bacteria communicate and coordinate behavior with one another - is a key driver of delayed healing in wounds infected by S. aureus. The findings suggest that by using drugs to interfere with quorum sensing, it could be possible to enhance wound healing without relying on antibiotics, reducing the risk of resistance and improving healing outcomes for patients.

Promising Biomarkers for Chronic Wound Healing: A Pilot Cohort Study on Wound Cytokines and a Novel Biofilm Detection Kit for Predicting 90-Day Outcomes - Wiley.com
Article by Yu-Feng Wu, Shu-Yun Sheu, Nai-Chen Cheng and Chao-Min Cheng (Taiwan - Wound Repair and Regeneration). Authors' findings highlight the limited reliability of clinical signs alone and emphasise the value of objective biofilm detection and cytokine profiling in wound prognosis. Their high-accuracy prediction model, based on readily accessible clinical variables and Wound Biofilm Detection Kit results, may facilitate precision wound care and improve real-time management.

Intermittent Electrical Stimulation-Induced Contractions Accelerate Pro-Regenerative Processes in Muscles With Deep Tissue Injury in Rats - Wiley.com
Article by Hemalatha Velanki, Neil Tyreman, Peter Seres, Leandro R. Solis, Steven Lu et al. (Edmonton, Canada - Wound Repair and Regeneration). Authors' results suggest that when applied early after the initiation of a deep tissue pressure injury, intermittent electrical stimulation can expedite anti-inflammatory and pro-regenerative events and may be an effective means for treating the injury.

Application of Biomaterials in Diabetic Wound Healing: The Recent Advances and Pathological Aspects - Mdpi.com
Article by Chenglong Han, Rajeev K. Singla and Chengshi Wang (China, India - Pharmaceutics). This article comprehensively reviews the pathological mechanisms of diabetic wounds. It also summarizes the application progress of biomaterials in diabetic wound healing. Over the past decade, researchers have explored the properties, mechanisms of action, and roles of various natural and synthetic biomaterials.

Two-drug combination shows promise in helping heal chronic wounds - Technology.org
University of Oregon researchers have tested a new combination drug therapy that could dismantle the difficult-to-treat bacteria inhabiting chronic wound infections. Their findings, published in the journal Applied and Environmental Microbiology, illuminate ways to develop more effective antimicrobial treatments that promote healing in chronic wounds. Such treatments also could help reduce the risk of severe infections that sometimes lead to amputations, such as diabetic foot ulcers.

Curcumin-Functionalized Ag and ZnO Nanoparticles: A Nanotherapeutic Approach for Treating Infections in Diabetic Wounds - Mdpi.com
Article by Mahboubeh Dolatyari, Parisa Rostami, Mahya Rostami, Ali Rostami and Hamit Mirtagioglu (Iran, Turkey - Bioengineering). The authors' findings demonstrate that curcumin-functionalized Ag-ZnO nanoparticles offer a safe and highly effective therapeutic strategy, providing robust antibacterial action and significantly accelerated wound healing.

Application of Antimicrobial Peptides in Wound Dressings - Tandfonline.com
Article by Aoxun Zhu, Baiqi Chen, Jing Ma, Jiajia Wang et al. (Yancheng - Drug Design, Development and Therapy). Authors identify key challenges and propose future directions: rational design of tailored AMPs, smart controlled‑release carriers, nanotechnology‑enabled formulations, and strategies to accelerate clinical translation.

Wound Healing: Molecular Mechanisms, Antimicrobial Peptides, and Emerging Technologies in Regenerative Medicine - Mdpi.com
Article by Ana Paula de Araújo Boleti,Ana Cristina Jacobowski,Breno Emanuel Farias Frihling, Maurício Vicente Cruz et al. (Brazil - Pharmaceuticals). The review addresses strategies to overcome bacterial biofilms and highlights promising approaches including biomaterials, nanomedicine, gene therapy, peptide-loaded nanoparticles, and the application of organoids as advanced platforms for studying and enhancing wound repair.

Extensive Wound Management of a Retroperitoneal Abscess Due to Complicated Pyelonephritis in a Patient With Type 2 Diabetes: A Case Reports - Cureus.com
Article by Benjamin Jesus Moya-Leal, Luis Adrian Alvarez-Lozada, Diego Escamilla-Magaña, Hugo Enrique Hernandez-Gamboa and Maria Fernanda Balderas-Sandoval (Monterrey, Mexico). This case highlights the importance of a comprehensive and staged approach in managing complex wounds resulting from deep infections in vulnerable patients. The combination of local antimicrobial treatment, negative pressure therapy, and skin grafting enabled effective recovery, without the need for extensive surgical interventions.

Chitosan Nanofibers Boost Wound Healing in Rats - Bioengineer.org
The synthesis of chitosan nanofibrous dressings could pave the way for new treatment paradigms that not only enhance the speed of healing but also ensure safety and comfort for patients. The future of wound care is indeed bright, promising not only to heal injuries but also to foster a healthier planet through responsible innovation in medical technology.

Development, Characterization, and Biological Evaluation of a Self-Healing Hydrogel Patch Loaded with Ciprofloxacin for Wound Dressings - Mdpi.com
Article by Wasan Al-Farhan, Osama H. Abusara, Mohammad Abu-Sini,Suhair Hikmat et al. (Amman, Jordan - Polymers). The cytotoxicity study revealed that the ciprofloxacin HCl hydrogel patch is non-cytotoxic. Additionally, the in vivo study demonstrated that this patch possesses wound-healing ability.

Soft bioelectronics embedded with self-confined tetrahedral DNA circuit for high-fidelity chronic wound monitoring - Nature.com
Article by Xiao Zhao, Jiahao Huang, Juncheng Zhang, Bowen Yang et al. (Nanjing, China - Nature Communications). The wireless platform demonstrates accurate in-situ monitoring of both non-infected and infected wounds on diabetic male mice without hindering the healing process, offering quantitative and comprehensive evaluation to guide treatment.

The Safety of Negative-Pressure Wound Therapy in Melanoma and Sarcoma Patients: A Systematic Review - Mdpi.com
Article by Silvia Dal Pos, Stela Tafaj, Ilda Hoxhaj, Fortunato Cassalia et al. (Italy - JCM). Current evidence does not suggest an increased risk of local recurrence associated with NPWT in melanoma or sarcoma patients, and mostly, NPWT may have important advantages over standard surgical dressings.

Exosome Therapy for Chronic Wound Healing - Lww.com
Article by Lucas Basamage, Hee Jin Ahn, Ho-Sung Choi, Carlos Roberto Antonio et al. (Brazil, South Korea - PRS Global Open). Exosome therapy was well tolerated and associated with rapid granulation, improved perfusion, and durable closure of refractory chronic ulcers. Although limited by small sample size and lack of controls, these findings support further controlled trials to define efficacy and optimize dosing.

Recent Progress in Polyphenol-Based Hydrogels for Wound Treatment and Monitoring - Mdpi.com
Article by Lulu Liu, Wenrui Ma, Junju Wang, Xiang Wang and Shunbo Li (China - Biosensors). This review aims to provide valuable insights for advancing polyphenol-based hydrogels, not only in their design, preparation, and application for wound healing and intelligent management but also in their future development potential.

Aging: the wound that never starts healing - Nature.com
Article by Mikolaj Ogrodnik (Vienna, Austria - Nature Communications). Here, it is argued that during aging, organs become locked in the early stages of the “healing process” that phenotypically correspond to the inflammatory phase. The damage responses activated within this state include the induction of cellular senescence, inflammation, LDs deposition, ECM remodeling, histolysis, and the infiltration of immune cells. Possibly, the “injury-like” perception of tissues undergoing aging originates from accumulated damage or its immediate consequences, such as DAMPs and PAMPs.

Smart Hydrogels in Wearable Electronics for Wound Treatments - Wiley.com
Article by Boyuan Li, Min Li and Yi Wang (Hong Kong, China - Small). By incorporating sensing, responsive controlled release, and dynamic interactive design, smart hydrogels enable dynamic wound treatment, demonstrating notable advantages. The advancements of smart hydrogels within the field of wearable electronics are summarized, elucidating their innovative fabrication techniques, critical functional properties, and integration into intelligent wound care systems through wearable technologies.